Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Autoantibody-negative insulin-dependent Diabetes MESHD after COVID-19

    Authors: Tim Hollstein; Juliane Schulz; Andreas Glück; Dominik M Schulte; Stefan Schreiber; Stefan R Bornstein; Matthias Laudes

    doi:10.21203/rs.3.rs-39343/v1 Date: 2020-07-01 Source: ResearchSquare

    Here we report the manifestation of insulin dependent diabetes MESHD after a COVID-19 infection MESHD in the absence of typical autoantibodies for type 1 diabetes MESHD. A 19-year-old Caucasian male TRANS subject presented to our emergency department with diabetic ketoacidosis HP diabetic ketoacidosis MESHD ( DKA MESHD). C-peptide levels accounted to 0.62µg/L in the presence of blood SERO glucose concentrations of 30.6 mmol/L (552 mg/dL). The patient´s case history revealed a COVID-19 disease 6-8 weeks prior to admission. This is of interest, since COVID-19 internalization into host cells is mediated via Angiotensin-converting enzyme 2 (ACE2) [1], a transmembrane glycoprotein which amongst others is crucial for β-cell homeostasis and function [2,3,4]. Detailed laboratory testing was performed, revealing no serum SERO- antibodies SERO against islet-cells (ICA), glutamic acid decarboxylase (GAD65-AA), tyrosine phosphatase (IA-2-AA), insulin (IAA) and zinc-transport-8 (ZnT8-AA), but against COVID-19. Hence, this is a presentation of an insulin-dependent diabetes mellitus MESHD diabetes mellitus HP in the absence of markers of autoimmunity HP, which might suggest direct cytolytic effects of COVID-19 on pancreatic β-cells presumably mediated via ACE2.

    Missing during COVID-19 lockdown: children TRANS with new-onset type 1 diabetes MESHD

    Authors: Devi Dayal; Saniya Gupta; Dhvani Raithatha; Muralidharan Jayashree

    doi:10.21203/rs.3.rs-28594/v1 Date: 2020-05-12 Source: ResearchSquare

    The redistribution of healthcare resources for coronavirus 2019 (COVID-19) pandemic has resulted in unintentional neglect of essential non-COVID-19 care (1). In low- and lower-middle income countries (LMIC), the already overstretched healthcare systems have crumbled under the COVID-19 pressure (2). Additionally, hardline lockdown restrictions, and fear of exposure to severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in healthcare settings have forced patients with non-COVID-19 illnesses to stay home and suffer until their illness deteriorates substantially, and sometimes irreversibly.  The impact of COVID-19 on the pediatric population has so far been mild, except in children TRANS with comorbidities (3). However, children TRANS who develop new time-sensitive non-COVID-19 illnesses during the pandemic are at risk of worsening or death MESHD due to compromised access to hospital care. In particular, children TRANS with new-onset type 1 diabetes MESHD (T1D) may progress rapidly to diabetic ketoacidosis HP diabetic ketoacidosis MESHD ( DKA MESHD) if treatment with insulin is delayed, and are therefore at risk of increased morbidity and mortality. 

    Near-fatal experience due to delayed diagnosis of type 1 diabetes MESHD during the COVID-19 pandemic

    Authors: Devi Dayal; Saniya Gupta; Dhvani Raithatha; Prakash Soni; Surjeet Thapa; Arun Baranwal

    doi:10.21203/rs.3.rs-25337/v1 Date: 2020-04-25 Source: ResearchSquare

    The focus of national governments and the medical profession on the pandemic of coronavirus disease MESHD 2019 (COVID-19) has resulted in neglect of care for children TRANS with new onset illnesses. Type 1 diabetes MESHD (T1D), the most common endocrine disorder MESHD in children TRANS, is prone to rapid deterioration if not diagnosed in time. We recently encountered a child TRANS who presented in a critical condition and was later diagnosed to have diabetic ketoacidosis HP diabetic ketoacidosis MESHD. We discuss the circumstances arising out of the severe lockdown restrictions for COVID-19, which resulted in difficulties in accessing the healthcare services and caused significant delay in the diagnosis of T1D and a near-death experience. It is essential to keep the non-COVID healthcare services open for children TRANS with new onset illnesses and those with chronic conditions for timely access in order to reduce morbidity and mortality due to these conditions.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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