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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Dynamic liver function indexes monitoring and clinical characteristics in three types of COVID-19 patients

    Authors: Cheng Chen; Jie Jiang; Xiaoxiao Xu; Yiyang Hu; Yi Hu; Yu Zhao

    doi:10.1101/2020.05.13.20099614 Date: 2020-05-16 Source: medRxiv

    Background and Aims: The abnormal liver function and even liver failure MESHD related death MESHD were reported in the COVID-19 patients, but less of studies focus on the dynamic liver function changes. We analysed the liver function indexes of COVID-19 patients to explore the characteristics of liver function changes in patients with different severity. Methods: This study included 54 moderate, 50 severe, and 31 death MESHD nucleic acid-confirmed COVID-19 patients hospitalized at the central hospital of Wuhan, China. Epidemiological histories, clinical features, imaging materials, medications and especially major liver function laboratory tests were collected for analysis. Results: The clinical symptoms did not present any significant difference in the patients at admission, but the older male TRANS patients had pronounced mortality risk. The normal ratio of ALT, TB, and DBIL of moderate patients was 96.3%, 94.44%, and 98.15% separately at the first test, but 59.26% of patients showed declined ALB levels. The normal ratio of all liver function indexes declined after admission, but most abnormalities were mild (1-2 times of upper limit unit) and went back normal before discharge. In severe patients, the normal ratio of ALB dropped down to 30.61% at admission along with the dramatic impaired normal ratio of bilirubin at the second test. The severe patients liver function dysfunction was worse than the moderate patients but without a significant difference. The dead patients showed a significantly higher level of DBIL, AST, GGT and CRP than other groups patients in the final test, along with the hypoalbuminemia MESHD hypoalbuminemia HP. What is worse, 16.13% of non-survivors were diagnosed with liver failure MESHD. No medication was found to be related to ALT, AST, and GGT abnormality in our study. Conclusion: In moderate and severe patients, liver dysfunction was mild. Patients widely presented lower level of ALB. The higher level of bilirubin, AST, and GGT was likely to indicate the worse outcome. Dynamic monitoring of liver function indexes could be considered and liver failure MESHD related death MESHD should be noticed and prevented in the early stage.

    Liver histopathology in COVID 19 infection MESHD is suggestive of vascular alteration

    Authors: aurelio sonzogni

    doi:10.1101/2020.05.06.20092718 Date: 2020-05-11 Source: medRxiv

    COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection MESHD very few information are available about liver involvement in COVID-19 infection MESHD, that could possibly evocate a systemic disease MESHD targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease MESHD. Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection MESHD were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease MESHD or signs of liver failure MESHD before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation MESHD features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation HP, partial or complete recent luminal thrombosis MESHD of portal and sinusoidal vessels, fibrosis MESHD fibrosis of portal HP of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection MESHD infection confirm TRANS confirm the clinical impression that liver failure MESHD is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood SERO vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood SERO vessels.

    Liver and COVID 19 Infection MESHD: A Very Preliminary Lesson Learnt from Histological Post-mortem Findings in 48 patients

    Authors: Aurelio Sonzogni; Giulia Previtali; Michela Seghezzi; Maria Grazia Alessio; Andrea Gianatti; Lisa Licini; Pietro Zerbi; Luca Carsana; Roberta Rossi; Eleonora Lauri; Alessandro Pellegrinelli; Manuela Nebuloni

    id:10.20944/preprints202004.0438.v1 Date: 2020-04-24 Source: Preprints.org

    COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection MESHD very few information are available about liver involvement in COVID-19 infection MESHD, that could possibly evocate a systemic disease MESHD targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease MESHD.Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection MESHD were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease MESHD or signs of liver failure MESHD before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation MESHD features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation HP, partial or complete recent luminal thrombosis MESHD of portal and sinusoidal vessels, fibrosis MESHD fibrosis of portal HP of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection MESHD infection confirm TRANS confirm the clinical impression that liver failure MESHD is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood SERO vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood SERO vessels.

    Cerebrovascular complications in patients with SARS-CoV-2 infection MESHD: Case series 

    Authors: Mauro Morassi; Daniele Bagatto; Milena Cobelli; Serena D’Agostini; Gian Luigi Gigli; Claudio Bnà; Alberto Vogrig

    doi:10.21203/rs.3.rs-23137/v1 Date: 2020-04-15 Source: ResearchSquare

    Background: Italy is one of the most affected countries by the Coronavirus disease MESHD 2019 (COVID-19). The responsible pathogen is named Severe Acute Respiratory Syndrome MESHD Coronavirus (SARS-CoV-2). The clinical spectrum ranges from asymptomatic infection MESHD asymptomatic TRANS infection to severe HP pneumonia MESHD pneumonia HP leading to intensive care unit admission. Evidence of cerebrovascular complications associated with SARS-CoV-2 is limited. We herein report 6 patients who developed acute stroke MESHD stroke HP during COVID-19 infection MESHD. Methods: Retrospective case series of patients diagnosed with COVID-19 using reverse-transcriptase–polymerase-chain-reaction (RT-PCR) on nasopharyngeal swabs, who developed clinical and neuroimaging evidence of acute stroke MESHD stroke HP during SARS-CoV-2 infection MESHD.Results: Six patients were identified (5 men); median age TRANS was 69 years (range: 57-82). Stroke MESHD Stroke HP subtypes were ischemic (4, 67%) and hemorrhagic (2, 33%). All patients but 1 had pre-existing vascular risk factors. One patient developed encephalopathy HP prior to stroke MESHD stroke HP, characterized by focal seizures MESHD seizures HP and behavioral abnormalities HP. COVID-19-related pneumonia MESHD pneumonia HP was severe (i.e. requiring critical care support) in 5/6 cases (83%). Liver enzyme alteration and lactate dehydrogenase (LDH) elevation was registered in all cases. Four patients (67%) manifested acute kidney failure prior to stroke MESHD stroke HP. Four patients (67%) had abnormal coagulation tests. Outcome was poor in the majority of the patients: 4 died (67%), 1 is still in coma MESHD coma HP (20%) and the remaining 1 remains severely neurologically affected (mRS: 4).Conclusions: Acute stroke MESHD stroke HP can complicate the course of COVI-19 infection MESHD. In our series, stroke MESHD stroke HP developed mostly in patients with severe pneumonia MESHD pneumonia HP and multi organ failure, liver MESHD enzymes and LDH were markedly increased in all cases, and the outcome was poor.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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