Corpus overview


MeSH Disease

Human Phenotype


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    COVID-19, What Could Sepsis MESHD Sepsis HP, Severe Acute Pancreatitis HP Pancreatitis MESHD, Gender TRANS Differences and Aging Teach Us?

    Authors: Claudio Gallo; Sirio Fiorino; Giovanni Posabella; Donato Antonacci; Antonio Tropeano; Emanuele Pausini; Carlotta Pausini; Tommaso Guarniero; Marco Zancanaro

    id:202007.0414/v1 Date: 2020-07-19 Source:

    Severe COVID-19 disease MESHD is characterised by an exaggerated inflammatory response, called cytokine storm, accompanied by a condition of immune depression. Even sepsis MESHD sepsis HP is characterised by an exaggerated inflammatory response, called SIRS ( Systemic Inflammatory Response Syndrome MESHD), accompanied by a condition of immune depression called CARS (compensatory anti-inflammatory response syndrome MESHD). Clinical studies reveal that most sepsis MESHD sepsis HP patients who did not die during the hyper inflammatory response (SIRS) subsequently succumbed to the condition of immune depression (CARS). Severe acute pancreatitis HP pancreatitis MESHD begins with local inflammation MESHD that induces systemic inflammatory response syndrome MESHD (SIRS), accompanied and followed by a compensatory anti-inflammatory response (CARS). In COVID-19 disease MESHD, the male TRANS response to SARS CoV-2 virus is typically characterised by a robust inflammatory response. Instead, a cell-mediated immune response is dominant in women. This means that the male TRANS sex tends to have a more robust hyper inflammatory response than the female TRANS one. Furthermore, in women the condition of immune depression is less represented, therefore they are more protected. Sepsis MESHD Sepsis HP, severe acute pancreatitis HP pancreatitis MESHD and COVID-19 disease MESHD evolve between two fundamental aspects: hyper inflammation MESHD and immunodepression. The experience gained over years of studies of sepsis MESHD sepsis HP and severe acute pancreatitis HP pancreatitis MESHD suggests that therapies should be differentiated according to the evolutionary stage of the disease MESHD. The goal is to save the lives of most patients with COVID-19 disease MESHD. The identification of critical points, suitable for designing the windows of therapeutic opportunity, may allow the use of therapeutic interventions, in the COVID-19 disease MESHD, which are effective (there are no approved drugs yet), safe (without significant side effects), targeted (based on the evolutionary phase of the disease MESHD) personalized, (based on sex, co-morbidities, age TRANS, etc.) and timely (based on signs, symptoms MESHD, laboratory parameters and instrumental investigations).

    Alterations in the host transcriptome in vitro and in vivo following severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD

    Authors: Xiaomei Lei; Zhijun Feng; Xiaojun Wang; Xiaodong He

    doi:10.21203/ Date: 2020-06-23 Source: ResearchSquare

    Background. Exploring alterations in the host transcriptome following SARS-CoV-2 infection MESHD is not only highly warranted to help us understand molecular mechanisms of the disease MESHD, but also provide new prospective for screening effective antiviral drugs, finding new therapeutic targets, and evaluating the risk of systemic inflammatory response syndrome MESHD (SIRS) early.Methods. We downloaded three gene expression matrix files from the Gene Expression Omnibus (GEO) database, and extracted the gene expression data of the SARS-CoV-2 infection MESHD and non- infection MESHD in human samples and different cell line samples, and then performed gene set enrichment analysis (GSEA), respectively. Thereafter, we integrated the results of GSEA and obtained co-enriched gene sets and co-core genes in three various microarray data. Finally, we also constructed a protein-protein interaction (PPI) network and molecular modules for co-core genes and performed Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis for the genes from modules to clarify their possible biological processes and underlying signaling pathway. Results. A total of 11 co-enriched gene sets were identified from the three various microarray data. Among them, 10 gene sets were activated, and involved in immune response and inflammatory reaction. 1 gene set was suppressed, and participated in cell cycle. The analysis of molecular modules showed that 2 modules might play a vital role in the pathogenic process of SARS-CoV-2 infection MESHD. The KEGG enrichment analysis showed that genes from module one enriched in signaling pathways related to inflammation MESHD, but genes from module two enriched in signaling of cell cycle and DNA replication. Particularly, necroptosis signaling, a newly identified type of programmed cell death MESHD that differed from apoptosis, was also determined in our findings. Additionally, for patients with SARS-CoV-2 infection MESHD, genes from module one showed a relatively high-level expression while genes from module two showed low-level. Conclusions. We identified two molecular modules were used to assess severity and predict the prognosis of the patients with SARS-CoV-2 infection MESHD. In addition, these results provide a unique opportunity to explore more molecular pathways as new potential targets on therapy in COVID 19.

    Severe colon ischemia MESHD in patients with severe COVID-2019 infection MESHD: a report of three cases

    Authors: Ana Almeida; Víctor Valentí Azcárate; Carlos Sánchez Justicia; Fernando Martínez Regueira; Pablo Martí-Cruchaga; Javier A. Cienfuegos; Fernando Rotellar

    doi:10.21203/ Date: 2020-05-25 Source: ResearchSquare

    Severe disease MESHD caused by the SARS-CoV coronavirus is characterized by patients presenting with respiratory distress HP associated with a systemic inflammatory response syndrome MESHD (cytokine storm). Sixteen to thirty percent of COVID-19 patients also have gastrointestinal symptoms. Here we present three cases of COVID-19 who developed colonic ischemia MESHD. Three males TRANS aged TRANS 76, 68 and 56 with respiratory distress HP and receiving mechanical ventilation presented episodes of rectal bleeding, abdominal distension and signs of peritoneal irritation. Endoscopy (case 1) and computed tomography angiography revealed colonic ischemia MESHD and pneumoperitoneum MESHD.One patient (case 2) underwent surgery in which perforation of the gangrenous cecum and colonic ischemia MESHD was confirmed.In all three patients D-dimer levels were markedly increased (2170, 2100 and 7360 ng/mL). All three patients died shortly after diagnosis.In severe COVID-19 disease MESHD, the pathogenic cause has increasingly become attributed to the development of disseminated intravascular coagulation MESHD disseminated intravascular coagulation HP secondary to the systemic inflammatory response.

    National Early Warning Score 2 (NEWS2) on admission predicts severe disease MESHD and in-hospital mortality from Covid-19 - A prospective cohort study

    Authors: Marius Myrstad; Håkon Ihle-Hansen; Anders Aune Tveita; Elizabeth Lyster Andersen; Ståle Nygård; Arnljot Tveit; Trygve Berge

    doi:10.21203/ Date: 2020-05-21 Source: ResearchSquare

    Background There is a need for validated clinical risk scores to identify patients at risk of severe disease MESHD and to guide decision-making during the covid-19 pandemic. The National Early Warning Score 2 (NEWS2) is widely used in emergency MESHD medicine, but so far, no studies have evaluated its use in patients with covid-19. We aimed to study the performance SERO of NEWS2 and compare commonly used clinical risk stratification tools at admission to predict risk of severe disease MESHD and in-hospital mortality in patients with covid-19. Methods This was a prospective cohort study in a public non-university general hospital in the Oslo area, Norway, including a cohort of all 66 patients hospitalised with confirmed SARS-CoV-2 infection MESHD from the start of the pandemic; 13 who died during hospital stay and 53 who were discharged alive. Data were collected consecutively from March 9th to April 27th 2020. The main outcome was the ability of the NEWS2 score and other clinical risk scores at emergency MESHD department admission to predict severe disease MESHD and in-hospital mortality in covid-19 patients. We calculated sensitivity SERO and specificity with 95% confidence intervals (CIs) for NEWS2 scores ≥5 and ≥6, quick Sequential Organ Failure Assessment (qSOFA) score ≥2, ≥2 Systemic Inflammatory Response Syndrome MESHD (SIRS) criteria, and CRB-65 score ≥2. Areas under the curve (AUCs) for the clinical risk scores were compared using DeLong’s test.Results In total, 66 patients (mean age TRANS 67.9 years) were included. Of these, 23% developed severe disease MESHD. In-hospital mortality was 20%. Tachypnoea, hypoxemia HP and confusion MESHD confusion HP at admission were more common in patients developing severe disease MESHD. A NEWS2 score ≥6 at admission predicted severe disease MESHD with 80.0% sensitivity SERO and 84.3% specificity (Area Under the Curve (AUC) 0.822, 95% confidence interval (CI) 0.690-0.953). NEWS2 was superior to qSOFA score ≥2 (AUC 0.624, 95% CI 0.446-0.810, p<0.05) and other clinical risk scores for this purpose.Conclusion NEWS2 score at hospital admission predicted severe disease MESHD and in-hospital mortality, and was superior to other widely used clinical risk scores in patients with covid-19.

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MeSH Disease
Human Phenotype

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