Corpus overview


MeSH Disease

Human Phenotype


    displaying 41 - 50 records in total 73
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    Ethnically diverse mutations in PIEZO1 associate with SARS-CoV-2 positivity

    Authors: Chew W Cheng; Vijayalakshmi Deivasikamani; Melanie J Ludlow; Dario De Vecchis; Antreas C Kalli; David J Beech; Piruthivi Sukumar

    doi:10.1101/2020.06.01.20119651 Date: 2020-06-03 Source: medRxiv

    COVID-19, caused by the SARS-CoV-2 virus, carries significant risk of mortality and has spread globally with devastating societal consequences. Endothelial infection MESHD has been identified as a feature of the disease and so there is motivation to determine the relevance of endothelial membrane mechanisms affecting viral entry and response. Here, through a study of patient data in UK Biobank released on 16 April 2020, we suggest relevance of PIEZO1, a non-selective cation channel protein that both mediates endothelial responses to mechanical force and unusually indents the cell membrane. PIEZO1 notably has roles that may also be relevant in red blood SERO cell function, pulmonary inflammation MESHD, bacterial infection MESHD and fibrotic auto-inflammation MESHD. We provide evidence that single nucleotide polymorphisms (SNPs) in the gene encoding PIEZO1 are more common in individuals who test positive for SARS-CoV-2 regardless of pre-existing hypertension HP hypertension MESHD, myocardial infarction HP myocardial infarction MESHD, stroke HP stroke MESHD, diabetes mellitus HP diabetes mellitus MESHD or arthritis HP arthritis MESHD. Some of these SNPs are more common in African and Caribbean populations, which are groups that were recently shown to have greater susceptibility to infection. One of the SNPs is a missense mutation that results in an amino acid change in an evolutionarily conserved and previously unexplored N-terminal region PIEZO1. The data support the notion of genetic factors influencing SARS-CoV-2 infection MESHD and suggest a specific role for PIEZO1.

    Central Nervous System Disorders MESHD in Severe SARS-CoV-2 Infection MESHD: detailed clinical work-up of eight cases

    Authors: Emanuela Keller; Giovanna Brandi; Sebastian Winklhofer; Lukas Imbach; Daniel Kirschenbaum; Karl Joachim Frontzek; Peter Steiger; Sabeth Aurelia Dietler; Marcellina Isabelle Haeberlin; Jan Folkard Willms; Francesca Porta; Adrian Waeckerlin; Irene Alma Abela; Andreas Lutterotti; Christoph Stippich; Ilijas Jelcic

    doi:10.21203/ Date: 2020-05-29 Source: ResearchSquare

    Objective Case series with different clinical presentations indicating central nervous system (CNS) involvement in coronavirus disease MESHD 2019 (COVID-19) have been published. Comprehensive work-ups including clinical characteristics, laboratory, electroencephalography (EEG), neuroimaging and cerebrospinal fluid (CSF) findings are needed to understand the mechanisms.DesignWe evaluated 32 consecutive patients with severe SARS-CoV-2 infection MESHD treated at a tertiary care centre from March 09 to April 03, 2020 for concomitant severe central nervous system (CNS) symptoms occurring during their critical disease state. Those with CNS disorders MESHD were examined in detail regarding clinical characteristics and undergoing additional examinations, e.g. computed tomography (CT), magnetic resonance imaging (MRI), (EEG), (CSF) analysis and autopsy if they had died.ResultsOf 32 critically ill patients with COVID-19 eight (18%) had severe CNS involvement (mean [SD] age TRANS, 67.6 [6.8] years; seven men; two patients died). All eight patients had cardiovascular risk factors, most frequently arterial hypertension HP hypertension MESHD. Two patients presented with lacunar ischemic stroke HP ischemic stroke MESHD and one with status epilepticus HP status epilepticus MESHD in the early phase. As most common presentation, six patients presented with prolonged impaired consciousness MESHD after termination of analgosedation. In all but one with delayed wake-up, neuroimaging or autopsy showed multiple cerebral microbleeds, in three of them with additional subarachnoid haemorrhage MESHD and in another two with additional small ischemic lesions MESHD. In three patients intracranial vessel wall sequence MRI was performed, for the first time to our knowledge. All cases showed contrast-enhancement of vessel walls in large and middle-sized cerebral arteries, suggesting vascular wall pathologies with an inflammatory component. CSF analysis showed normal cells counts and chemistry. RT-PCRs for SARS-CoV-2 in CSF were all negative, and no intrathecal SARS-CoV-2 specific IgG synthesis was detectable. ConclusionsCNS disorders MESHD are common in patients with severe COVID-19. Different mechanisms might be involved. Besides unspecific encephalopathy HP encephalopathy MESHD and encephalitic syndromes MESHD, large vessel strokes HP strokes MESHD might occur early after disease onset. In a later phase, microbleeds and microinfarctions indicate potential CNS small vessel disease. MRI vessel wall contrast enhancement suggests cerebral vascular wall pathologies with an inflammatory component. CNS disorders MESHD associated with COVID-19 may lead to long-term disabilities aggravating socio-economic damage. The mechanisms have to be investigated urgently in order to develop preventive and therapeutic neuroprotective strategies.

    Stroke HP Stroke MESHD as a an initial presentation of  SARS-COV2 infection MESHD: a brief report

    Authors: maria buccafusca; massimo autunno; masina cotroneo; antonio giovanni versace; giuseppe nunnari

    doi:10.21203/ Date: 2020-05-29 Source: ResearchSquare

    The novel Coronavirus 19 infection spread rapidly from Wuhan, Hubei Province – China, to the worldwide, becoming a pandemic. The infection does not cause only flu-like syndrome MESHD ( fever HP fever MESHD, dry cough and shortness of breath MESHD) and respiratory distress HP of varying severity but also affects the kidneys, the heart, the nervous system and the circulatory apparatus, causing thromboembolic MESHD events. Usually these problems occur in patients with severe respiratory failure HP respiratory failure MESHD admitted to Intensive Care Unit and with pre-existing comorbidities.We report the case of a patient without Covid symptoms who had thrombotic stroke MESHD stroke HP as the presenting features of Coronavirus infection MESHD.

    Characteristics of Ischemic Stroke HP Stroke MESHD in COVID-19: A Need for Early Detection and Management

    Authors: Dinesh V. Jillella; Nicholas J. Janocko; Fadi Nahab; Karima Benameur; James G. Greene; Wendy L. Wright; Mahmoud Obideen; Srikant Rangaraju

    doi:10.1101/2020.05.25.20111047 Date: 2020-05-26 Source: medRxiv

    Objective: In the setting of the Coronavirus Disease MESHD 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke HP stroke MESHD has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke HP ischemic stroke MESHD ( AIS MESHD). Methods: This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke HP ischemic stroke MESHD admitted to an academic health system in metropolitan Atlanta (USA) between March 24th,2020, and May 5th, 2020. Demographic, clinical, and radiographic characteristics were described. Results: Of 124 ischemic stroke HP ischemic stroke MESHD stroke MESHD patients admitted during this study period, 8 (6.5%) were also diagnosed with COVID-19. The mean age TRANS of patients was 64.3 +/- 6.5 years, 5 (62.5%) male TRANS, mean time from last-normal was 4.8 days [SD 4.8], and none received acute reperfusion therapy. All 8 patients had at least one stroke HP stroke MESHD-associated co-morbidity. The predominant pattern of ischemic stroke HP ischemic stroke MESHD was embolic MESHD; 3 were explained by atrial fibrillation HP atrial fibrillation MESHD while 5 (62.5%) were cryptogenic. In contrast, cryptogenic strokes HP strokes MESHD were seen in 20 (16.1%) of 124 total stroke HP stroke MESHD admissions during this time. Conclusions: In our case series, ischemic stroke HP ischemic stroke MESHD affected COVID-19 patients with traditional stroke HP stroke MESHD risk factors with an age TRANS of stroke HP stroke MESHD presentation typically seen in non-COVID populations. We observed a predominantly embolic pattern of stroke MESHD stroke HP with a higher than expected rate of cryptogenic strokes HP strokes MESHD and with a prolonged median time to presentation and symptom recognition limiting the use of acute reperfusion treatments. These results highlight the need for increased community awareness, early identification, and management of AIS in COVID-19 patients.

    Total and Stroke HP Stroke MESHD Related Imaging Utilization Patterns During the COVID-19 Pandemic

    Authors: Long Hoang Tu; Richa Sharma; Ajay Malhotra; Joseph L Schindler; Howard P Forman

    doi:10.1101/2020.05.20.20078915 Date: 2020-05-26 Source: medRxiv

    During the COVID-19 pandemic, radiology practices are reporting a decrease in imaging volumes. We review total imaging volume, CTA head and neck volume, critical results rate, and stroke HP stroke MESHD intervention rates before and during the COVID-19 pandemic. Total imaging volume as well as CTA head and neck imaging fell HP approximately 60% since the beginning of the pandemic. Critical results fell HP 60-70% for total imaging as well as for CTA head and neck. Compared to the same time frame a year prior, the number of stroke HP stroke MESHD codes at the early impact of the pandemic had decreased approximately 50%. Proportional reductions in total imaging volume, stroke HP stroke MESHD-related imaging, and associated critical result reports during the COVID-19 pandemic raise concern for missed stroke HP stroke MESHD diagnoses in our population.

    Acutely Altered Mental Status as the Main Clinical Presentation of Multiple Strokes HP Strokes MESHD in Critically Ill Patients With COVID-19.

    Authors: Carolina Díaz-Pérez; Carmen Ramos; Alberto López-Cruz; José Muñoz Olmedo; Jimena Lázaro González; Enrique de Vega-Ríos; Carmen González-Ávila; Carlos Hervás; Santiago Trillo; José Vivancos

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background and aims: Cerebral infarction MESHD in COVID-19 patients might be associated with a hypercoagulable state related to a systemic inflammatory response. Its diagnosis might be challenging. We present two critically ill patients with COVID-19 who presented acutely altered mental status as the main manifestation of multiple strokes MESHD strokes HP.Methods:Clinical presentation and diagnostic work-up of the patients.Results:Two patients in their sixties were hospitalized with a bilateral pneumonia HP COVID-19. They developed respiratory failure HP respiratory failure MESHD and were admitted to ICU for mechanical ventilation and intense medical treatment. They were started on low-molecular-weight heparin since admission. Their laboratory results showed lymphopenia HP lymphopenia MESHD and increased levels of C-reactive protein and D-dimer. Case 1 developed hypofibrinogenemia HP and presented several cutaneous lesions with biopsy features of thrombotic vasculopathy MESHD. Case 2 was performed a CT pulmonary angiogram at ICU showing a bilateral pulmonary embolism HP pulmonary embolism MESHD. When waking up, both patients were conscious but with a remarkable global altered mental status without focal neurological deficits MESHD. A brain MRI revealed multiple acute bilateral ischemic lesions MESHD with areas of hemorrhagic MESHD transformation in both patients (Case 1: affecting the left frontal and temporal lobes MESHD and both occipital lobes; Case 2: affecting both frontal and left occipital lobes). Cardioembolic source and acquired antiphospholipid syndrome MESHD were ruled out. COVID-19-associated coagulopathy MESHD was suspected as the possible main etiology of the strokes HP strokes MESHD.Conclusion:Acutely altered mental status might be the main manifestation of multiple brain infarctions MESHD in critically ill COVID-19 patients. It should be specially considered in those with suspected COVID-19-associated coagulopathy MESHD. Full-dose anticoagulation and clinical-radiological monitoring might reduce their neurological consequences.

    COVID-19 impact on consecutive neurological patients admitted to the emergency department

    Authors: Andrea Pilotto; Alberto Benussi; Ilenia Libri; Stefano Masciocchi; Loris Poli; Enrico Premi; Antonella Alberici; Enrico Baldelli; Sonia Bonacina; Laura Brambilla; Matteo Benini; Salvatore Caratozzolo; Matteo Cortinovis; Angelo Costa; Stefano Cotti Piccinelli; Elisabetta Cottini; Viviana Cristillo; Ilenia Delrio; Massimiliano Filosto; Massimo Gamba; Stefano Gazzina; Nicola Gilberti; Stefano Gipponi; Marcello Giunta; Alberto Imarisio; Paolo Liberini; Martina Locatelli; Francesca Schiano Di Cola; Renata Rao; Barbara Risi; Luca Rozzini; Andrea Scalvini; Veronica Vergani; Irene Volonghi; Nicola Zoppi; Barbara Borroni; Mauro Magoni; Matilde Leonardi; Gainluigi Zanusso; Sergio Ferrari; Sara Mariotto; Alessandro Pezzini; Roberto Gasparotti; Ciro Paolillo; Alessandro Padovani

    doi:10.1101/2020.05.23.20110650 Date: 2020-05-26 Source: medRxiv

    Abstract Objective: Aim of this study was to analyse the impact of COVID-19 on clinical and laboratory findings and outcome of neurological patients consecutively admitted to the emergency department (ED) of a tertiary hub center. Methods: All adult TRANS patients consecutively admitted to the ED for neurological manifestations from February 20 th through April 30 th 2020 at Spedali Civili of Brescia entered MESHD the study. Demographic, clinical, and laboratory data were extracted from medical records and compared between patients with and without COVID-19. Results: Out of 505 consecutively patients evaluated at ED with neurological symptoms MESHD, 147 (29.1%) tested positive for SARS-CoV-2. These patients displayed at triage higher values of CRP, AST, ALT, and fibrinogen but not lymphopenia HP lymphopenia MESHD (p<0.05). They were older (73.1 + 12.4 vs 65.1 + 18.9 years, p=0.001) had higher frequency of stroke HP stroke MESHD (34.7% vs 29.3%), encephalitis HP encephalitis MESHD/ meningitis HP (9.5% vs 1.9%) and delirium HP delirium MESHD (16.3% vs 5.0%). Compared to patients without COVID, they were more frequently hospitalized (91.2% vs 69.3%, p<0.0001) and showed higher mortality rates (29.7% vs 1.8%, p<0.0.001) and discharge disability, independently from age TRANS. Conclusions: COVID-19 impacts on clinical presentation of neurological disorders MESHD, with higher frequency of stroke HP stroke MESHD, encephalitis HP encephalitis MESHD and delirium HP, and was strongly associated with increased hospitalisation, mortality and disability.

    Psychological impact of Covid-19 lockdown in India: Different strokes HP strokes MESHD for different folks

    Authors: Anupam Joya Sharma; Malavika Ambale Subramanyam

    doi:10.1101/2020.05.25.20111716 Date: 2020-05-26 Source: medRxiv

    The psychological impact of the lockdown due to the Covid-19 pandemic are widely documented. In India, a family-centric society with a high population density and extreme social stratification, the impact of the lockdown might vary across diverse social groups. However, the patterning in the psychological impact of the lockdown among sexual minorities and persons known to be at higher risk of contracting Covid-19 is not known in the Indian context. We used mixed methods (online survey, n=282 and in-depth interviews, n=14) to investigate whether the psychological impact of the lockdown was different across these groups of Indian adults TRANS. We fitted linear and logistic regression models adjusted for sociodemographic covariates. Thematic analysis helped us identify emergent themes in our qualitative narratives. Anxiety HP Anxiety MESHD was found to be higher among sexual minorities ({beta}=2.44, CI: 0.58, 4.31), high-risk group ({beta}=2.20, CI:0.36, 4.05), and those with history of depression/loneliness MESHD ({beta}=3.89, CI:2.34, 5.44). Addiction to pornography was also found to be higher among sexual minorities ({beta}=2.72, CI: 0.09, 5.36). Qualitative findings suggested that sexual minorities likely used pornography and masturbation to cope with the lockdown, given the limited physical access to sexual partners in a society that stigmatizes homosexuality. Moreover, both qualitative and quantitative study findings suggested that greater frequency of calling family members TRANS during lockdown could strengthen social relationships and increase social empathy. The study thereby urgently calls for the attention of policymakers to take sensitive and inclusive health decisions for the marginalized and the vulnerable, both during and after the crisis.

    Characteristics and predictors of hospitalization and death MESHD in the first 9,519 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: A nationwide cohort

    Authors: Mette Reilev; Kasper Bruun Kristensen; Anton Pottegaard; Lars Christian Lund; Jesper Hallas; Martin Thomsen Ernst; Christian Fynbo Christiansen; Henrik Toft Soerensen; Nanna Borup Johansen; Nikolai Constantin Brun; Marianne Voldstedlund; Henrik Stoevring; Marianne Kragh Thomsen; Steffen Christensen; Sophie Gubbels; Tyra Grove Krause; Kaare Moelbak; Reimar Wernich Thomsen

    doi:10.1101/2020.05.24.20111823 Date: 2020-05-26 Source: medRxiv

    Objective To provide population-level knowledge on individuals at high risk of severe and fatal coronavirus disease MESHD 2019 (COVID-19) in order to inform targeted protection strategies in the general population and appropriate triage of hospital contacts. Design, Setting, and Participants Nationwide population-based cohort of all 228.677 consecutive Danish individuals tested (positive or negative) for severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) RNA from the identification of the first COVID-19 case on February 27th, 2020 until April 30th, 2020. Main Outcomes and Measures We examined characteristics and predictors of inpatient hospitalization versus community-management, and death MESHD versus survival, adjusted for age TRANS-, sex- and number of comorbidities. Results We identified 9,519 SARS-CoV-2 PCR-positive cases of whom 78% were community-managed, 22% were hospitalized (3.2% at an intensive care unit) and 5.5% had died within 30 days. Median age TRANS varied from 45 years (interquartile range (IQR) 31-57) among community-managed cases to 82 years (IQR 75-89) among those who died. Age TRANS was a strong predictor of fatal disease (odds ratio (OR) 14 for 70-79-year old, OR 26 for 80-89-year old, and OR 82 for cases older than 90 years, when compared to 50-59-year old and adjusted for sex and number of comorbidities). Similarly, the number of comorbidities was strongly associated with fatal disease MESHD (OR 5.2, for cases with [≥]4 comorbidities versus no comorbidities), and 82% of fatal cases had at least 2 comorbidities. A wide range of major chronic diseases MESHD were associated with hospitalization with ORs ranging from 1.3-1.4 (e.g. stroke, ischemic HP stroke, ischemic MESHD ischemic MESHD heart disease MESHD) to 2.2-2.7 (e.g. heart failure MESHD, hospital-diagnosed kidney disease, chronic HP kidney disease, chronic MESHD chronic liver disease MESHD). Similarly, chronic diseases MESHD were associated with mortality with ORs ranging from 1.2-1.3 (e.g. ischemic MESHD heart disease MESHD, hypertension HP hypertension MESHD) to 2.4-2.7 (e.g. major psychiatric disorder MESHD, organ transplantation). In the absence of comorbidities, mortality was relatively low (5% or less) in persons aged TRANS up to 80 years. Conclusions and Relevance In this first nationwide population-based study, increasing age TRANS and number of comorbidities were strongly associated with hospitalization requirement and death MESHD in COVID-19. In the absence of comorbidities, the mortality was, however, lowest until the age TRANS of 80 years. These results may help in accurate identification, triage and protection of high-risk groups in general populations, i.e. when reopening societies.

    Incidence and consequences of systemic arterial thrombotic MESHD events in COVID-19 patients

    Authors: Estefanía Cantador MD; Alberto Núñez MD; Pilar Sobrino MD; Victoria Espejo MD; Lucía Fabia MD; Lydia Vela MD, PhD; Luis de Benito MD, PhD; Javier Botas MD, PhD, FESC

    doi:10.21203/ Date: 2020-05-23 Source: ResearchSquare

    A high incidence of thrombotic MESHD events, particularly deep vein thrombosis MESHD and pulmonary embolism HP pulmonary embolism MESHD, has been clearly documented in COVID-19 patients. In addition, small series of patients with coronary, cerebrovascular MESHD and peripheral arterial thrombotic MESHD events have also been reported, but their true incidence and consequences are not well described, and constitute the objective of this study. From February 1st to April 21st, 2020, 2,115 COVID-19 patients were treated at Hospital Universitario Fundación Alcorcón (Madrid, Spain), and 1,419 were eventually admitted. Patient characteristics and outcomes were collected by reviewing their electronic medical records. Fourteen patients had a systemic arterial thrombotic event, which represents a 1% incidence in relation to the total number of hospitalized patients. Three patients suffered an acute coronary syndrome MESHD, two with persistent ST-segment elevation HP, one of whom was treated invasively, and one with transient ST-segment elevation HP. Eight patients had a cerebrovascular event. Six suffered an acute ischemic stroke HP ischemic stroke MESHD and two a transient ischemic attack HP ischemic MESHD attack, 50% of them had a Rankin score ≥3 at discharge. Three additional patients had a limb thrombotic MESHD event, all of them infrapopliteal, and were managed conservatively.  All three cases developed necrosis of the toes MESHD, two of them with bilateral involvement. The hospitalization death rate of patients with an arterial event was 28.6%. Although COVID-19 may favor the occurrence of thrombotic MESHD events, the destabilization and thrombosis of arterial HP thrombosis of arterial MESHD atherosclerotic plaques do not seem to be a frequent mechanism which warrants the need for specific systematic preventive measures.

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MeSH Disease
Human Phenotype

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