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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Neurological Involvement of Coronavirus Disease MESHD 2019: A Systematic Review

    Authors: Malik Ghannam; Qasem Alshaer; Mustafa Al-Chalabi; Lara Zakarna; Jetter Robertson; Georgios Manousakis

    doi:10.21203/rs.3.rs-31183/v1 Date: 2020-05-23 Source: ResearchSquare

    Background: In December 2019, unexplained cases of pneumonia HP pneumonia MESHD emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease MESHD 2019 (COVID-2019) outbreak, a pandemic. Although the most common presentations of COVID-19 are fever HP fever MESHD, cough HP cough MESHD and shortness of breath MESHD, several clinical observations indicate that COVID-19 does affect the central and peripheral nervous system.  Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 that were evident for neurological involvement.  Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age TRANS was 62.28 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n=40) had cerebrovascular insults, 28% (n=23) had neuromuscular disorders MESHD, 18.3% of the patients (n=15) had encephalitis HP encephalitis MESHD or encephalopathy HP encephalopathy MESHD, and 2.4% (n=2) presented with status epilepticus HP status epilepticus MESHD. Conclusions: Neurological manifestations of COVID-19 infection MESHD are not rare, especially large vessel stroke HP stroke MESHD, Guillain barre syndrome MESHD and meningoencephalitis MESHD. Moving forward, further studies are needed to clarify the prevalence SERO of the neurological complications of COVID-19, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.

    Risk of Ischemic Stroke HP Ischemic Stroke MESHD in Patients with Covid-19 versus Patients with Influenza

    Authors: Alexander E. Merkler; Neal S. Parikh; Saad Mir; Ajay Gupta; Hooman Kamel; Eaton Lin; Joshua Lantos; Edward J. Schenck; Parag Goyal; Samuel S. Bruce; Joshua Kahan; Kelsey N. Lansdale; Natalie M. LeMoss; Santosh B. Murthy; Philip E. Stieg; Matthew E. Fink; Costantino Iadecola; Alan Z. Segal; Thomas R. Campion; Ivan Diaz; Cenai Zhang; Babak B. Navi

    doi:10.1101/2020.05.18.20105494 Date: 2020-05-21 Source: medRxiv

    Importance: Case series without control groups suggest that Covid-19 may cause ischemic stroke HP ischemic stroke MESHD, but whether Covid-19 is associated with a higher risk of ischemic stroke HP ischemic stroke MESHD than would be expected from a viral respiratory infection MESHD is uncertain. Objective: To compare the rate of ischemic stroke HP ischemic stroke MESHD stroke MESHD between patients with Covid-19 and patients with influenza, a respiratory viral illness previously linked to stroke HP stroke MESHD. Design: A retrospective cohort study. Setting: Two academic hospitals in New York City. Participants: We included adult TRANS patients with emergency department visits or hospitalizations with Covid-19 from March 4, 2020 through May 2, 2020. Our comparison cohort included adult TRANS patients with emergency department visits or hospitalizations with influenza A or B from January 1, 2016 through May 31, 2018 (calendar years spanning moderate and severe influenza seasons). Exposures: Covid-19 infection confirmed TRANS by evidence of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in the nasopharynx by polymerase chain reaction, and laboratory-confirmed influenza A or B. Main Outcomes and Measures: A panel of neurologists adjudicated the primary outcome of acute ischemic stroke MESHD ischemic stroke HP and its clinical characteristics, etiological mechanisms, and outcomes. We used logistic regression to compare the proportion of Covid-19 patients with ischemic stroke HP ischemic stroke MESHD versus the proportion among patients with influenza. Results: Among 2,132 patients with emergency department visits or hospitalizations with Covid-19, 31 patients (1.5%; 95% confidence interval [CI], 1.0%-2.1%) had an acute ischemic stroke HP ischemic stroke MESHD. The median age TRANS of patients with stroke HP stroke MESHD was 69 years (interquartile range, 66-78) and 58% were men. Stroke HP Stroke MESHD was the reason for hospital presentation in 8 (26%) cases. For our comparison cohort, we identified 1,516 patients with influenza, of whom 0.2% (95% CI, 0.0-0.6%) had an acute ischemic stroke HP ischemic stroke MESHD. After adjustment for age TRANS, sex, and race, the likelihood of stroke HP stroke MESHD was significantly higher with Covid-19 than with influenza infection MESHD (odds ratio, 7.5; 95% CI, 2.3-24.9). Conclusions and Relevance: Approximately 1.5% of patients with emergency department visits or hospitalizations with Covid-19 experienced ischemic stroke HP ischemic stroke MESHD, a rate 7.5-fold higher than in patients with influenza. Future studies should investigate the thrombotic MESHD mechanisms in Covid-19 in order to determine optimal strategies to prevent disabling complications like ischemic stroke HP ischemic stroke MESHD.

    Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19

    Authors: Viktoria Schwarz; Felix Mahfoud; Lucas Lauder; Wolfgang Reith; Stefanie Behnke; Sigrun Smola; Jürgen Rissland; Thorsten Pfuhl; Bruno Scheller; Michael Böhm; Sebastian Ewen

    doi:10.21203/rs.3.rs-30359/v1 Date: 2020-05-19 Source: ResearchSquare

    Background The spread of the novel coronavirus SARS-CoV-2 and the guidance from authorities for social distancing and media reporting lead to significant uncertainty in Germany. As concerns have been expressed regarding the underdiagnosing of harmful diseases. We explored the rates of emergency presentations for acute coronary syndrome MESHD ( ACS MESHD) and acute cerebrovascular events (ACVE) before and after spread of SARS-CoV-2. Methods We analyzed all-cause visits at a tertiary university emergency department and admissions for ACS MESHD and ACVE before (calendar weeks 1 to 9, 2020) and after (calendar weeks 10 to 16, 2020) the first coronavirus disease MESHD (COVID-19) case in the region of the Saarland, Germany. The data were compared with the same period of the previous year. Results In 2020 an average of 346 patients per week presented at the emergency department whereas in 2019 an average of 400 patients presented up to calendar week 16 (p=0.018; whole year 2019 = 395 patients per week). After the first COVID-19 diagnosis in the region, emergency department visit volume decreased by 30% compared with the same period in 2019 (p=0.0012). Admissions due to ACS MESHD decreased by 41% (p=0.0023 for all; Δ -71% (p=0.007) for unstable angina MESHD, Δ -25% (p=0.42) for myocardial infarction HP myocardial infarction MESHD with ST-elevation and Δ -17% (p=0.28) without ST-elevation) compared with the same period in 2019 and decreased from 142 patients in calendar weeks 1 to 9 to 62 patients in calendar weeks 10 to 16. ACVE decreased numerically by 20% (p=0.25 for all; transient ischemic attack HP ischemic MESHD attack: Δ -32% (p=0.18), ischemic stroke HP ischemic stroke MESHD: Δ -23% (p=0.48), intracerebral haemorrhage MESHD: Δ +57% (p=0.4)). There was no significant change in ACVE per week (p=0.7) comparing calendar weeks 1 to 9 (213 patients) and weeks 10 to 16 (147 patients). Testing of 3756 samples was performed to detect 58 SARS-CoV-2 positive patients ( prevalence SERO 1,54%, thereof one patient with myocardial and two with cerebral ischemia HP cerebral ischemia MESHD) up to calendar week 16 in 2020. Conclusions The COVID-19 pandemic was associated with a significant decrease in all-cause admission and admissions due to cardiovascular events MESHD in the emergency department. Regarding acute cerebrovascular events there was a numerical decrease but no significant difference.

    Decline in Emergent and Urgent Care during the COVID-19 Pandemic

    Authors: Dhruv S Kazi; Rishi K Wadhera; Changyu Shen; Kalon K.L. Ho; Rushad Patell; Magdy H. Selim; John H. Urwin; Mark L. Zeidel; Peter Zimetbaum; Kevin Tabb; Robert W. Yeh

    doi:10.1101/2020.05.14.20096602 Date: 2020-05-18 Source: medRxiv

    Due to the ongoing coronavirus disease MESHD (COVID-19) pandemic, there are concerns that patients may be avoiding care for emergent and urgent health conditions due to fear of contagion or as an unintentional consequence of government orders to postpone non-essential services. We therefore sought to evaluate the effect of the COVID-19 pandemic on the number of patient encounters for select emergent or urgent diagnoses at a large tertiary-care academic medical center in Boston. Inpatient diagnoses included acute myocardial infarction HP myocardial infarction MESHD ( MI MESHD) and stroke HP stroke MESHD, and outpatient but urgent diagnoses included new referrals for breast and hematologic malignancies MESHD. For each condition, we used a difference-in-differences approach to estimate the proportional change in number of encounters during the pandemic (March-April 2020) compared with earlier in the same year (January-February 2020), using equivalent periods in 2019 as a control. After the onset of the pandemic, we observed significant reductions in hospitalizations for MI MESHD (difference-in-differences estimate, 0.67; 95%CI, 0.46-0.96; P=0.04) and stroke HP stroke MESHD (difference-in-differences estimate, 0.42; 95%CI, 0.28-0.65; P<0.001) (Table). In the ambulatory setting, there was a reduction in referrals for breast cancer MESHD and hematologic cancers MESHD, but this did not reach statistical significance until the month after the onset of the pandemic. Our findings suggest an urgent need for public health messaging to ensure that patients continue to seek care for acute emergencies MESHD. In addition, decisions by health systems regarding when to reinitiate non-emergent care should carefully factor in the harms of delayed diagnosis and treatment occurring during the COVID-19 pandemic.

    Behavioural change towards reduced intensity physical activity is disproportionately prevalent among adults TRANS with serious health issues or self-perception of high risk during the UK COVID-19 lockdown.

    Authors: Nina Trivedy Rogers; Naomi Waterlow; Hannah E Brindle; Luisa Enria; Rosalind M Eggo; Shelley Lees; Chrissy h Roberts

    doi:10.1101/2020.05.12.20098921 Date: 2020-05-18 Source: medRxiv

    Importance: There are growing concerns that the UK COVID-19 lockdown has reduced opportunities to maintain health through physical activity, placing individuals at higher risk of chronic disease MESHD and leaving them more vulnerable to severe sequelae of COVID-19. Objective: To examine whether the UK's lockdown measures have had disproportionate impacts on intensity of physical activity in groups who are, or who perceive themselves to be, at heightened risk from COVID-19. Designs, Setting, Participants: UK-wide survey of adults TRANS aged TRANS over 20, data collected between 2020-04-06 and 2020-04-22. Exposures: Self-reported doctor-diagnosed obesity HP obesity MESHD, hypertension HP hypertension MESHD, type I/ II diabetes MESHD, lung disease MESHD, cancer MESHD, stroke HP stroke MESHD, heart disease MESHD. Self-reported disabilities and depression MESHD. Sex, gender TRANS, educational qualifications, household income, caring for school- age TRANS children TRANS. Narrative data on coping strategies. Main Outcomes and Measures: Change in physical activity intensity after implementation of UK COVID-19 lockdown (self-reported). Results: Most (60%) participants achieved the same level of intensity of physical activity during the lockdown as before the epidemic. Doing less intensive physical activity during the lockdown was associated with obesity HP obesity MESHD (OR 1.21, 95% CI 1.02-1.41), hypertension HP hypertension MESHD (OR 1.52, 1.33-1.71), lung disease MESHD (OR 1.31,1.13-1.49), depression MESHD (OR 2.02, 1.82-2.22) and disability (OR 2.34, 1.99-2.69). Participants who reduced their physical activity intensity also had higher odds of being female TRANS, living alone or having no garden, and more commonly expressed sentiments about personal or household risks in narratives on coping. Conclusions and relevance: Groups who reduced physical activity intensity included disproportionate numbers of people with either heightened objective clinical risks or greater tendency to express subjective perceptions of risk. Policy on exercise for health during lockdowns should include strategies to facilitate health promoting levels of physical activity in vulnerable groups, including those with both objective and subjective risks.

    COVID-19 and Crosstalk With the Hallmarks of Aging

    Authors: Shabnam Salimi; John M. Hamlyn

    id:10.20944/preprints202004.0182.v2 Date: 2020-05-16 Source: Preprints.org

    Within the past several decades, the emergence of new viral diseases MESHD with severe health complications and mortality is evidence of an age TRANS-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2 MESHD, SARS-CoV-2, causes coronavirus disease MESHD 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases MESHD and those with a compromised immune system regardless of age TRANS and in older adults TRANS who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia HP pneumonia MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome, lung fibrosis MESHD, cardiovascular events, acute kidney injury HP acute kidney injury MESHD, stroke HP stroke MESHD, hospitalization, and mortality have been reported that result from pathogen–host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults TRANS, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging coupled with host–coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections MESHD, including immunosenescence, inflammation MESHD and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction MESHD, telomere attrition, epigenetic alterations, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults TRANS and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of anti-aging drug candidates that require paramount attention in COVID-19 research.

    Pre-existing Cardiovascular Disease MESHD in United States Population at High Risk for Severe COVID-19 Infection

    Authors: Adnan I Qureshi

    doi:10.1101/2020.05.11.20089714 Date: 2020-05-15 Source: medRxiv

    Background and Purpose There is increasing recognition of a relatively high burden of pre-existing cardiovascular disease MESHD in Corona Virus Disease MESHD 2019 (COVID 19) infected MESHD patients. We determined the burden of pre-existing cardiovascular disease MESHD in persons residing in United States (US) who are at risk for severe COVID-19 infection MESHD. Methods Age TRANS (60 years or greater), presence of chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD, diabetes, mellitus HP diabetes, mellitus MESHD mellitus MESHD, hypertension HP hypertension MESHD, and/or malignancy were used to identify persons at risk for admission to intensive care unit, or invasive ventilation, or death MESHD with COVID-19 infection MESHD. Persons were classified as low risk (no risk factors), moderate risk (1 risk factor), and high risk (two or more risk factors present) using nationally representative sample of US adults TRANS from National Health and Nutrition Examination Survey 2017 and 2018 survey. Results Among a total of 5856 participants, 2386 (40.7%) were considered low risk, 1325 (22.6%) moderate risk, and 2145 persons (36.6%) as high risk for severe COVID-19 infection MESHD. The proportion of patients who had pre-existing stroke HP stroke MESHD increased from 0.6% to 10.5% in low risk patients to high risk patients (odds ratio [OR]19.9, 95% confidence interval [CI]11.6-34.3). The proportion of who had pre-existing myocardial infection MESHD ( MI MESHD) increased from 0.4% to 10.4% in low risk patients to high risk patients (OR 30.6, 95% CI 15.7-59.8). Conclusions A large proportion of persons in US who are at risk for developing severe COVID 19 infection MESHD are expected to have pre-existing cardiovascular disease MESHD. Further studies need to identify whether targeted strategies towards cardiovascular diseases MESHD can reduce the mortality in COVID-19 infected MESHD patients.

    The association of cardiovascular disease MESHD and other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis

    Authors: Paddy Ssentongo; Anna E. Ssentongo; Emily S. Heilbrunn; Djibril M Ba; Vernon M. Chinchilli

    doi:10.1101/2020.05.10.20097253 Date: 2020-05-14 Source: medRxiv

    Background Exploring the association of coronavirus-2019 disease (COVID-19) mortality with chronic pre-existing conditions may promote the importance of targeting these populations during this pandemic to optimize survival. The objective of this systematic review and meta-analysis is to explore the association of pre-existing conditions with COVID-19 mortality. Methods We searched MEDLINE, OVID databases, SCOPUS, and medrxiv.org for the period December 1, 2019, to May 1, 2020. The outcome of interest was the risk of COVID-19 mortality in patients with and without pre-existing conditions. Comorbidities explored were cardiovascular diseases MESHD ( coronary artery disease MESHD, hypertension HP hypertension MESHD, cardiac arrhythmias MESHD arrhythmias HP, and congestive heart failure HP congestive heart failure MESHD), chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD, type 2 diabetes MESHD, cancer MESHD, chronic kidney disease HP chronic kidney disease MESHD, chronic liver disease MESHD, and stroke HP stroke MESHD. Two independent reviewers extracted data and assessed the risk of bias. All analyses were performed using random-effects models and heterogeneity was quantified. Results Ten chronic conditions from 19 studies were included in the meta-analysis (n = 61,455 patients with COVID-19; mean age TRANS, 61 years; 57% male TRANS). Overall the between-study study heterogeneity was medium and studies had low publication bias MESHD and high quality. Coronary heart disease MESHD, hypertension HP hypertension MESHD, congestive heart failure HP congestive heart failure MESHD, and cancer MESHD significantly increased the risk of mortality from COVID-19. The risk of mortality from COVID-19 in patients with coronary heart disease MESHD was 2.4 times as high as those without coronary heart disease MESHD (RR= 2.40, 95%CI=1.71-3.37, n=5) and twice as high in patients with hypertension HP hypertension MESHD as high as that compared to those without hypertension HP hypertension MESHD (RR=1.89, 95%CI= 1.58-2.27, n=9). Patients with cancer MESHD also were at twice the risk of mortality from COVID-19 compared to those without cancer MESHD (RR=1.93 95%CI 1.15-3.24, n=4), and those with congestive heart failure HP congestive heart failure MESHD were at 2.5 times the risk of mortality compared to those without congestive heart failure HP congestive heart failure MESHD (RR=2.66, 95%CI 1.58-4.48, n=3). Conclusions COVID-19 patients with all any cardiovascular disease MESHD, coronary heart disease MESHD, hypertension HP hypertension MESHD, congestive heart failure HP congestive heart failure MESHD, and cancer MESHD have an increased risk of mortality. Tailored infection MESHD prevention and treatment strategies targeting this high-risk population are warranted to optimize survival.

    A Rapid Decrease in Stroke HP Stroke MESHD, Acute Coronary Syndrome MESHD, and Corresponding Interventions at 65 United States Hospitals Following Emergence of COVID-19

    Authors: Adam de Havenon; John Ney; Brian Callaghan; Alen Delic; Sam Hohmann; Ernie Shippey; Shadi Yaghi; Mohammad Anadani; Gregory Esper; Jennifer Majersik

    doi:10.1101/2020.05.07.20083386 Date: 2020-05-11 Source: medRxiv

    Background Following the emergence of coronavirus disease MESHD 2019 (COVID-19), early reports suggested a decrease in stroke HP stroke MESHD and acute coronary syndrome MESHD ( ACS MESHD). We sought to provide descriptive statistics for stroke HP stroke MESHD and ACS MESHD from a sample of hospitals throughout the United States, comparing data from March 2020 to similar months pre-COVID. Methods We performed a retrospective analysis of 65 academic and community hospitals in the Vizient Clinical Data Base. The primary outcome is monthly count of stroke HP stroke MESHD and ACS MESHD, and acute procedures for both, from February and March in 2020 compared to the same months in 2018 and 2019. Results are aggregated for all hospitals and reported by Census Region. Results We identified 51,246 strokes HP strokes MESHD (42,780 ischemic MESHD, 8,466 hemorrhagic MESHD), 1,043 mechanical thrombectomies (MT), 836 tissue plasminogen activator (tPA) administrations, 36,551 ACS MESHD, and 3,925 percutaneous coronary interventions (PCI) for ACS MESHD. In February 2020, relative to February 2018 and 2019, hospitalizations with any discharge diagnosis of stroke HP stroke MESHD and ACS MESHD increased by 9.8% and 12.1%, respectively, while in March 2020 they decreased 18.5% and 7.5%, relative to March 2018 and 2019. When only including hospitalizations with the primary discharge diagnosis of stroke HP stroke MESHD or ACS MESHD, in March 2020 they decreased 17.6% and 25.7%, respectively. In March 2020, tPA decreased 3.3%, MT increased 18.8%, although in February 2020 it had increased 36.8%, and PCI decreased 14.7%. These decreases were observed in all Census regions. Conclusions Following greater recognition of the risks of COVID-19, hospitalizations with stroke HP stroke MESHD and ACS MESHD were markedly diminished in a geographically diverse sample of United States hospitals. Because the most likely explanation is that some patients with stroke HP stroke MESHD and ACS MESHD did not seek medical care, the underlying reasons for this decrease warrant additional study to inform public health efforts and clinical care during this and future pandemics.

    Etiologic Subtypes of Ischemic Stroke HP Ischemic Stroke MESHD in SARS-COV-2 Virus MESHD patients

    Authors: Ketevan Berekashvili; Adam A Dmytriw; Volodomyr Vulkanov; Shashank Agarwal; Amit Khaneja; David Turkel-Parella; Jeremy Liff; Jeffrey Farkas; Thambirajah Nandakumar; Ting Zhou; Jennnifer Frontera; David E Kahn; Sun Kim; Kelly A Humbert; Matthew D Sanger; Shadi Yaghi; Aaron Lord; Karthikeyan Arcot; Ambooj Tiwari

    doi:10.1101/2020.05.03.20077206 Date: 2020-05-08 Source: medRxiv

    Objective: To describe the ischemic stroke HP ischemic stroke MESHD etiopathogenesis related to COVID-19 in a cohort of NYC hospitals. Background: Extra-pulmonary involvement of COVID-19 has been reported in the hepatic, renal and hematological systems. Most neurological manifestations are non-focal but few have reported the characteristics of ischemic strokes HP ischemic strokes MESHD or investigated its pathophysiology. Methods: Over the last 6 weeks, data from four centers in New York City were collected to review the possible ischemic stroke HP ischemic stroke MESHD types seen in COVID-19 positive patients. Their presentation, demographics, other related vascular risk factors, associated laboratory and coagulation markers, as well as imaging and outcomes were collected. Results: In our study, age TRANS range of patients was 25-75 with no significant male TRANS preponderance. 70% presented for acute hospitalization due the stroke HP stroke MESHD. About a fifth did not have common risk factors for ischemic stroke HP ischemic stroke MESHD stroke MESHD like diabetes MESHD and hypertension HP hypertension MESHD. None had history of atrial fibrillation HP atrial fibrillation MESHD or smoking. 50% had poor outcome with four ending in mortality and one in a critical condition due ARDS. All had high Neutrophil/Lymphocyte ratio except one who demonstrated some neurological recovery. In 70% of our cases, D-dimer levels were collected, and all showed mild to severe elevation. None of the emergent large vessel occlusion (LVO) cases had known cardiac risk factors but two out of five were found to have cardiac abnormalities MESHD during the course of their hospitalization. All LVOs had hypercoagulable lab markers especially elevated D-dimer and/or Fibrinogen. The LVO patients were younger and sicker with a median age TRANS of 46 and mean NIHSS of 24 as opposed to non-LVOs with a median age TRANS of 62 and mean NIHSS of 6 respectively. Conclusion: COVID-19 related ischemic MESHD events can be small vessel, branch emboli MESHD or large vessel occlusions. The latter is often associated with either a hypercoagulable state or cardio-embolism MESHD. Patient outcomes were worse when multi-organ or pulmonary system failure MESHD prevailed. Keywords: COVID-19, Acute Ischemic strokes HP Ischemic strokes MESHD, Emergent Large Vessel Occlusion, Mechanical Thrombectomy MESHD

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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