Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (1)


Transmission

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Seroprevalence

antibody (1)

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    SARS-CoV-2 infection MESHD leads to acute infection MESHD with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

    Authors: Dhiraj K. Singh; Shashank R. Ganatra; Bindu Singh; Journey Cole; Kendra J. Alfson; Elizabeth Clemmons; Michal Gazi; Olga Gonzalez; Ruby Escabedo; Tae-Hyung Lee; Ayan Chatterjee; Yenny Goez-Gazi; Riti Sharan; Rajesh Thippeshappa; Maya Gough; Cynthia Alvarez; Alyssa Blakely; Justin Ferdin; Carmen Bartley; Hilary Staples; Laura Parodi; Jessica Callery; Amanda Mannino; Benjamin Klaffke; Priscilla Escareno; Roy N Platt; Vida Hodara; Julia Scordo; Adelekan Oyejide; Dharani K. Ajithdoss; Richard Copin; Alina Baum; Christos Kyratsous; Xavier Alvarez; Bruce Rosa; Mushtaq Ahmed; Anna Goodroe; John Dutton; Shannan Hall-Ursone; Patrice Frost; Andra K. Voges; Corinna N. Ross; Ken Sayers; Christopher Chen; Cory Hallam; Shabaana A Khader; Makedonka Mitreva; Tim Anderson; Luis Martinez-Sobrido; Jean Patterson; Joanne Turner; Jordi B. Torrelles; Edward J. Dick; Kathleen Brasky; Larry S. Schlesinger; Luis Giavedoni; Deepak Kaushal; Ricardo Carrion

    doi:10.1101/2020.06.05.136481 Date: 2020-06-05 Source: bioRxiv

    There are no known cures or vaccines for COVID-19, the defining pandemic of this era. Animal models are essential to fast track new interventions and nonhuman primate (NHP) models of other infectious diseases MESHD have proven extremely valuable. Here we compare SARS-CoV-2 infection MESHD in three species of experimentally infected NHPs (rhesus macaques, baboons, and marmosets). During the first 3 days, macaques developed clinical signatures of viral infection MESHD and systemic inflammation MESHD, coupled with early evidence of viral replication and mild-to-moderate interstitial and alveolar pneumonitis, as well as extra-pulmonary pathologies. Cone-beam CT scans showed evidence of moderate pneumonia MESHD pneumonia HP, which progressed over 3 days. Longitudinal studies showed that while both young and old macaques developed early signs of COVID-19, both groups recovered within a two-week period. Recovery was characterized by low-levels of viral persistence in the lung, suggesting mechanisms by which individuals with compromised immune systems may be susceptible to prolonged and progressive COVID-19. The lung compartment contained a complex early inflammatory milieu with an influx of innate and adaptive immune cells, particularly interstitial macrophages, neutrophils and plasmacytoid dendritic cells, and a prominent Type I-interferon response. While macaques developed moderate disease MESHD, baboons exhibited prolonged shedding of virus and extensive pathology following infection MESHD; and marmosets demonstrated a milder form of infection MESHD. These results showcase in critical detail, the robust early cellular immune responses to SARS-CoV-2 infection MESHD, which are not sterilizing and likely impact development of antibody SERO responses. Thus, various NHP genera recapitulate heterogeneous progression of COVID-19. Rhesus macaques and baboons develop different, quantifiable disease attributes MESHD making them immediately available essential models to test new vaccines and therapies.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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