Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 10 records in total 15
    records per page

    Does Cystic Fibrosis MESHD Constitute an Advantage in COVID-19 Infection MESHD?

    Authors: Valentino Bezzerri; Francesca Lucca; Sonia Volpi; Marco Cipolli

    doi:10.21203/ Date: 2020-08-04 Source: ResearchSquare

    The Veneto region is one of the most affected Italian regions by COVID-19. Chronic lung diseases HP lung diseases MESHD, such as chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (COPD), may constitute a risk factor in COVID-19. Moreover, respiratory viruses were generally associated with severe pulmonary impairment in cystic fibrosis MESHD (CF). We would have therefore expected numerous cases of severe COVID-19 among the CF population. Surprisingly, we found that CF patients were significantly protected against infection MESHD by SARS-CoV-2. We discussed this aspect formulating some reasonable theories.

    Association of Diabetes and Outcomes in Patients with COVID-19: A Propensity Score Matched Analyses from a French Retrospective Cohort

    Authors: Willy Sutter; Baptiste Duceau; Aurélie Carlier; Antonin Trimaille; Thibaut Pommier; Oriane Weizman; Joffrey Cellier; Laura Geneste; Vassili Panagides; Wassima Marsou; Antoine Deney; Sabir Attou; Thomas Delmotte; Sophie Ribeyrolles; Pascale Chemaly; Clément Karsenty; Gauthier Giordano; Alexandre Gautier; Corentin Chaumont; Pierre Guilleminot; Audrey Sagnard; Julie Pastier; maxime Vignac; delphine Mika; Charles Fauvel; Théo Pezel; Ariel Cohen; Guillaume Bonnet; Ronan Roussel; Louis POTIER

    doi:10.21203/ Date: 2020-07-31 Source: ResearchSquare

    Background: To compare the clinical outcomes between patients with and without diabetes admitted to hospital with COVID-19.Methods: Retrospective multicentre cohort study from 24 academic tertiary medical centres in France including 2851 patients (675 with diabetes) hospitalised for COVID-19 between February 26 and April 20, 2020. A propensity score matching method (1:1 matching including patient characteristics, medical history, vital signs, and laboratory results) was used to compare patients with and without diabetes (n=603 in each group). The primary outcome was admission to intensive care unit (ICU) or in-hospital death MESHD. Results: Patients with diabetes were older (71 ± 13 vs. 65 ± 18 years; p<0.001), were less often female TRANS (38% vs. 44%; p<0.001) and more likely to have comorbidities: hypertension MESHD hypertension HP (79% vs 42%; p<0.001), coronary heart disease MESHD (23% vs 9%; p<0.001), stroke MESHD stroke HP (13% vs 8%; p<0.001), heart failure MESHD (17% vs 9%; p<0.001), chronic kidney disease HP kidney disease MESHD (26% vs 10%; p<0.001), and chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (7% vs 5%; p<0.05). The primary outcome occurred in 584 (36.4%) patients with diabetes compared to 246 (26.8%) in those without diabetes (p<0.001). After propensity score matching, the risk of primary outcome was similar in patients with and without diabetes (hazard ratio [HR] 1.16, 95%CI 0.95-1.41, p=0.14) and was 1.29 (95%CI 0.97 – 1.69) for in-hospital mortality, 1.26 (95%CI 0.93 – 1.72) for mortality without transfer in ICU, and 1.14 (95%CI 0.88 – 1.47) for transfer to ICU.Conclusions: In this retrospective cohort of patients hospitalised for COVID-19, diabetes was not significantly associated with a higher risk of COVID-19 severe outcomes after propensity score matching.Trial registration NCT04344327

    Developing the nomogram for the prediction of in-hospital incidence of acute respiratory distress HP syndrome MESHD in patients with COVID-19

    Authors: Ning Ding; Yang Zhou; Guifang Yang; Cuirong Guo; Fengning Tang; Xiangping Chai

    doi:10.21203/ Date: 2020-07-26 Source: ResearchSquare

    Background: Acute respiratory distress HP syndrome MESHD (ARDS) was the most common complication of coronavirus disease MESHD-2019(COVID-19), leading to poor clinical outcomes. However, the model to predict the in-hospital incidence of ARDS in patients with COVID-19 is limited. Therefore, we aimed to develop a predictive nomogram for the in-hospital incidence of ARDS in COVID-19 patients.Methods: Patients with COVID-19 admitted to Changsha Public Health Centre between Jan 30, 2020, and Feb 22, 2020, were enrolled. Clinical characteristics and laboratory variables were analyzed in patients with ARDS. Risk factors for ARDS were selected by LASSO binary logistic regression. Nomogram was established based on risk factors and validated by the dataset.Results: A total of 113 patients, involving 99 in the non-ARDS group and 14 in the ARDS group were included in the study. 8 variables including hypertension MESHD hypertension HP, chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (COPD), cough MESHD cough HP, lactate dehydrogenase (LDH), creatine kinase (CK), white blood SERO count (WBC), body temperature, and heart rate were identified to be included in the model. The specificity, sensitivity SERO, and accuracy of the full model were 100%, 85.7%, and 87.5% respectively. The calibration curve also showed good agreement between the predicted and observed values in the model.Conclusions: The nomogram can predict the in-hospital incidence of ARDS in COVID-19 patients. It helps physicians to make an individualized treatment plan for each patient.

    Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy

    Authors: Stefano Ciardullo; Francesca Zerbini; Silvia Perra; Emanuele Muraca; Rosa Cannistraci; Marinella Lauriola; Paolo Grosso; Guido Lattuada; Giovanbattista Ippoliti; Andrea Mortara; Giuseppina Manzoni; Gianluca Perseghin

    doi:10.21203/ Date: 2020-06-18 Source: ResearchSquare

    Purpose. The purpose of this study was to evaluate the impact of pre-existing diabetes on in-hospital mortality in patients admitted for Coronavirus Disease MESHD 2019 (COVID-19).Methods. This is a single center, retrospective study conducted at Policlinico di Monza hospital, located in the Lombardy region, Northern Italy. We reviewed medical records of 373 consecutive adult TRANS patients who were hospitalized with COVID-19 between February 22 and May 15, 2020. Data were collected on diabetes status, comorbid conditions and laboratory findings. Multivariable logistic regression was performed to evaluate the effect of diabetes on in-hospital mortality after adjustment for potential confounding variables.Results. Mean age TRANS of the patients was 72 ± 14 years (range 17-98), 244 (65.4%) were male TRANS and 69 (18.5%) had diabetes. The most common comorbid conditions were hypertension MESHD hypertension HP (237 [64.8%]), cardiovascular disease MESHD (140 [37.7%]) and malignant neoplasms MESHD neoplasms HP (50 [13.6%]). In-hospital death MESHD occurred in 142 (38.0%) patients. In the multivariable model older age TRANS (Odds Ratio [OR] 1.07 [1.04-1.10] per year), diabetes (OR 2.2 [1.10-4.73]), chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (OR 3.30 [1.22-8.90]), higher values of lactic dehydrogenase and C-reactive protein were independently associated with in-hospital mortality.Conclusion. In this retrospective single-center study, diabetes was independently associated with a higher in-hospital mortality. More intensive surveillance of patients with this condition is to be warranted.

    Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio for predicting clinical outcomes in COVID-19

    Authors: Ting Zhang; Shaoping Huang; Min Liu; Xiaolu Li; Zhiyin Shang; Hongzhou Lu

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background The epidemic of 2019 novel coronavirus (COVID-19) struck China in late December,2019, resulting in about 200000 deaths MESHD all over the world. Numerous observational studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte proportion and the platelet-to-lymphocyte ratio (PLR) are inflammatory markers. Our study aimed to detect the role of NLR, PLR in predicting the prognosis of COVID-19.Results Four hundred and fifteen consecutive patients were enrolled in Shanghai Public Health Clinical Center affiliated to Fudan University, between 20 January and 11 April 2020 with confirmed COVID-19,among which 386 (93%) patients were not severe, and 27 (7%) were severe. The proportion of males TRANS in severe cases is higher than in non-severe cases (75.86% vs. 50.52%, P = 0.008). The age TRANS between the two groups is different (p = 0.022). Compared with non-severe patients, severe patients exhibited more comorbidities, including hypertension MESHD hypertension HP (48.28% vs. 19.43%, p < 0.001), diabetes (20.69% vs. 6.99%, p = 0.009), chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (51.72% vs. 6.22%, p < 0.001), and fatty liver MESHD (37.93% vs. 15.8%, p = 0.002), respectively. NLR and PLR showed significant difference (p < 0.001). Diabetes (OR 0.28; 95% CI 15.824-187.186), fatty liver MESHD (OR 21.469; 95% CI 2.306-199.872), coronary heart disease MESHD (OR 18.157; 95% CI 2.085-158.083), NLR (OR 1.729; 95% CI 1.050–2.847) were significantly associated with severe cases with COVID-19. The NLR of patients in severe group had a 1.729-fold higher than that of no-severe group (OR 1.729; 95% CI 1.050–2.847, P = 0.031).Conclusions NLR is an independent risk factor of severe COVID-19 patients. PLR, NLR were significantly different between severe and non-severe patients, so assessment of NLR, PLR may help identify high risk cases with COVID-19.

    Age TRANS-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis

    Authors: Krishna P. Maremanda; Isaac K. Sundar; Dongmei Li; Irfan Rahman

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Aging is one of the key contributing factors for chronic obstructive pulmonary diseases MESHD chronic obstructive pulmonary diseases HP (COPD) and other chronic inflammatory lung diseases MESHD. Cigarette smoke is a major etiological risk factor that has been shown to alter cellular processes involving mitochondrial function, cellular senescence and telomeric length. Here we determined how aging contribute to the alteration in the gene expression of above mentioned cellular processes that play an important role in the progression of COPD and IPF. We hypothesized that aging may differentially alter the expression of mitochondrial, cellular senescence and telomere genes in smokers and patients with COPD and IPF compared to non-smokers. Total RNA from human lung tissues from non-smokers, smokers, and patients with COPD and IPF were processed and analyzed based on their ages TRANS (younger: <55 yrs and older: >55 yrs). NanoString nCounter panel was used to analyze the gene expression profiles using a custom designed codeset containing 112 genes including 6 housekeeping controls (mitochondrial biogenesis and function, cellular senescence, telomere replication and maintenance). mRNA counts were normalized, log2 transformed for differential expression analysis using linear models in the limma package (R/Bioconductor). Data from non-smokers, smokers and patients with COPD and IPF were analyzed based on the age groups TRANS (pairwise comparisons between younger vs. older groups). Several genes were differentially expressed in younger and older smokers, and patients with COPD and IPF compared to non-smokers which were part of the mitochondrial biogenesis/function (HSPD1, FEN1, COX18, COX10, UCP2 & 3), cellular senescence (PCNA, PTEN, KLOTHO, CDKN1C, TNKS2, NFATC1 & 2, GADD45A) and telomere replication/maintenance (PARP1, SIRT6, NBN, TERT, RAD17, SLX4, HAT1) target genes. Interestingly, NOX4 and TNKS2 were increased in the young IPF as compared to the young COPD patients. Genes in the mitochondrial dynamics and other quality control mechanisms like FIS1 and RHOT2 were decreased in young IPF compared to their age TRANS matched COPD subjects. ERCC1 (Excision Repair Cross-Complementation Group 1) and GADD45B were higher in young COPD as compared to IPF. Aging plays an important role in various infectious diseases MESHD. Elderly TRANS patients with chronic lung disease HP lung disease MESHD and smokers were found to have high incidence and mortality rates in the current pandemic of SARS-CoV-2 infection MESHD. Immunoblot analysis in the lung homogenates of smokers, COPD and IPF subjects revealed increased protein abundance of important proteases and spike proteins like TMPRSS2, furin and DPP4 in association with a slight increase in SARS-CoV-2 receptor ACE2 levels. This may further strengthen the observation that smokers, COPD and IPF subjects are more prone to COVID-19 infection MESHD. Overall, these findings suggest that altered transcription of target genes that regulate mitochondrial function, cellular senescence, and telomere attrition add to the pathobiology of lung aging in COPD and IPF and other smoking-related chronic lung disease HP lung disease MESHD in associated with alterations in SARS-CoV-2 ACE2-TMPRSS2-Furin-DPP4 axis for COVID-19 infection MESHD.

    Extremely severe case of COVID-19 pneumonia MESHD pneumonia HP recovered despite bad prognostic indicators: a didactic report

    Authors: Enrico Bentivegna; M. Luciani; V Spuntarelli; M L Speranza; L Guerritore; A Sentimentale; P Martelletti

    doi:10.21203/ Date: 2020-06-08 Source: ResearchSquare

    Introduction: COVID-19 is a highly infectious respiratory disease MESHD caused by Severe Acute Respiratory Syndrome MESHD - Coronavirus - 2 (SARS-COV2). Starting from Wuhan (China) where it was firstly reported, it rapidly spread to the rest of the world, causing a pandemic with more than 300.000 deaths MESHD to date. Case presentation: we report an extremely severe case of coronavirus pneumonia MESHD pneumonia HP in an over-80 years old patient with hypertension MESHD hypertension HP, coronary heart disease MESHD, chronic heart failure MESHD and chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP. Despite several bad anamnestic indicators, the severe clinical conditions and complications that arose during hospitalization, the patient recovered and was discharged.Conclusions: Although a higher vulnerability of geriatric patients has been observed, the literature on elderly TRANS COVID-19 patients have remained very scarce, especially in those over 80. The aim of this paper is to describe an extremely severe case of coronavirus pneumonia MESHD pneumonia HP in an over-80 years old patient that, despite a clearly poor anamnestic and clinical prognostic forecast was successfully discharged thanks to a careful evaluation of the case and of the complications that have arisen. Several efforts have been made to identify therapeutic strategies and prognostic indicators of COVID-19 but there is still much to learn. With this report, we hope to provide important elements to better understand this disease MESHD.

    Association between symptoms and severity of disease MESHD in hospitalised novel coronavirus (COVID-19) patients: A systemic review and meta-analysis

    Authors: Ashis Talukder; Shaharior Rahman Razu; Sheikh Alif; Muhammad Aziz Rahman; Sheikh Mohammed Shariful Islam

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Symptoms of the novel coronavirus disease MESHD (COVD-19) are well known, although asymptomatic TRANS cases were also reported due to this rapidly evolving viral disease MESHD. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and diseases MESHD severity. We aimed to evaluate the association between symptoms and severity of disease MESHD in confirmed COVID-19 cases by performing a meta-analysis.Methods We conducted a systematic review by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease MESHD between 01-Jan-2020 and 20-Apr-2020. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Degree of heterogeneity among studies and quality of the selected studies were evaluated.Results Out of 153 articles identified, a total of seven articles, including 3,168 participants, met the inclusion criteria and were included. The median age TRANS of the patients was 49 years, 1818 (57.38%) were males TRANS, and 574 (18.11%) reported severe conditions. Fever MESHD Fever HP was the most commonly reported symptom in the reported COVID-19 confirmed cases TRANS (87.89%, 95% CI: 83.22–81.39%), which was followed by cough MESHD cough HP, myalgia MESHD myalgia HP or fatigue MESHD fatigue HP, and less proportionally dyspnea MESHD dyspnea HP and headache MESHD headache HP. Dyspnea MESHD Dyspnea HP was the only symptom, which was associated with severity of COVID-19 (OR 2.38, 95% CI: 1.83–3.10).Conclusions Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases MESHD chronic obstructive pulmonary diseases HP need to be careful about the onset of such symptom TRANS and should seek medical attention.

    The Main Risk Factors for the Number of Serious or Critical Cases of Covid-19: How is the Health of Brazilians?

    Authors: Haniel Fernandes

    id:10.20944/preprints202005.0143.v1 Date: 2020-05-08 Source:

    Chronic noncommunicable diseases MESHD (CNCDs) have been a major public health concern worldwide, especially diabetes, cardiovascular disease MESHD disease, chronic obstructive pulmonary HP chronic obstructive pulmonary disease MESHD, hypertension MESHD hypertension HP, in addition to obesity MESHD obesity HP, which is even more worrying when the subject involves the covid-19 pandemic, because such incidences correlate with the need for intensive care units, including the possibility of death MESHD of the patient. Therefore, for countries with the highest numbers of critical cases, it is important to assess the incidence of these diseases MESHD to guide the public that most needs guidance on public policies for social isolation.

    Identification of pulmonary comorbid diseases MESHD network based repurposing effective drugs for COVID-19

    Authors: Jai Chand Patel; Rajkumar Tulswani; Pankaj Khurana; Yogendra Kumar Sharma; Lilly Ganju; Bhuvnesh Kumar; Ragumani Sugadev

    doi:10.21203/ Date: 2020-05-08 Source: ResearchSquare

    The number of hospitalization of COVID-19 patients with one or more comorbid diseases MESHD is highly alarming. Despite the lack of large clinical data and incomplete understanding of virus pathology, identification of the COVID-19 associated diseases MESHD with clinical precision are highly limited. In this regard, our text mining of 6238 PubMed abstracts (as on 23 April 2020) successfully identified broad spectrum of COVID-19 comorbid diseases MESHD/disorders (54), and their prevalence SERO on the basis of the number of occurrence of disease MESHD terms in the abstracts. The disease MESHD ontology based semantic similarity network analysis revealed the six highly comorbid diseases MESHD of COVID-19 namely Viral Pneumonia MESHD Pneumonia HP, Pulmonary Fibrosis MESHD Pulmonary Fibrosis HP, Pulmonary Edema MESHD Pulmonary Edema HP, Acute Respiratory Distress HP Syndrome MESHD (ARDS), Chronic Obstructive Pulmonary Disease MESHD Chronic Obstructive Pulmonary Disease HP (COPD) and Asthma MESHD Asthma HP. The disease MESHD gene bipartite network revealed 15 genes that were strongly associated with several viral pathways including the corona viruses may involve in the manifestation (mild to critical) of COVID-19. Our tripartite network- based repurposing of the approved drugs in the world market revealed six promising drugs namely resveratrol, dexamethasone, acetyl cysteine, Tretinoin, simvastatin and aspirin to treat comorbid symptoms of COVID-19 patients. Our animal studies in rats and literatures strongly supported that resveratrol is the most promising drug to possibly reduce several comorbid symptoms associated with COVID-19 including the severe hypoxemia HP induced vascular leakage. Overall, the anti-viral properties of resveratrol against corona virus could be readily exploited to effectively control the viral load at early stage of COVID-19 infection MESHD through nasal administration.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.