Background: The early identification of patients suffering from SARS-CoV-2 infection MESHD
in primary care is of outmost importance in the current pandemic.Aim: To gain a better understanding of the specific symptoms of SARS-CoV-2 infection MESHD
in primary care.Design and setting: We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19.Methods: We examined the association between various symptoms and a positive test using univariate and multivariate logistic regression, adjusted for clustering within the laboratories.Results: Of the 1561 patients tested, 1543 agreed to participate (participation rate: 99%). Among them, 253 were positive for SARS-Cov-2 (16%). In multivariate analysis, loss of taste (OR 3.8 [95%CI 3.3-4.4], p-value<0.001), loss of smell (OR 3.0 [95%CI 1.9-4.8], p-value<0.001), muscle pain MESHD pain HP
(OR 1.6 [95%CI 1.2-2.0], p-value 0.001) and dry nose (OR 1.3 [95%CI 1.1-1.6], p-value 0.01) were significantly associated with a positive result. The strength of association with taste and smell disorders was higher for symptom combinations (OR 6.5 [95%CI 3.9-10.8] for loss of taste MESHD
and smell, OR 6.7 [95%CI 5.9-7.5] for loss of taste MESHD
or smell). In contrast, sore throat (OR 0.6 [95%CI 0.4-0.8], p-value 0.003), stuffy nose (OR 0.7 [95%CI 0.6-0.7], p-value<0.001), diarrhea HP diarrhea MESHD
(OR 0.6 [95%CI 0.5-0.6], p-value<0.001) and dyspnea HP dyspnea MESHD
(OR 0.5 [95%CI 0.3-0.7], p-value<0.001) were inversely associated with a positive test.Conclusion: Our data could further facilitate targeted screening and contribute to the triage and early identification of new clusters of cases.