Corpus overview


MeSH Disease

Human Phenotype


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    Covid-19 in Chile. The experience of a Regional reference Center. Preliminary report

    Authors: Felipe Olivares; Daniel Munoz; Alberto Fica; Ignacio Delama; Ignacia Alvarez; Maritza Navarrete; Eileen Blackburn; Pamela Garrido; Juan Granjean

    doi:10.1101/2020.06.14.20130898 Date: 2020-06-16 Source: medRxiv

    During the first pandemic wave Covid-19 reached Latin America cities. Aim: To report clinical features and outcomes associated to Covid-19 in a group of patients admitted during the first wave in a regional reference Center in southern Chile designated to severe and critical cases. Methods: Cases were identified by a compatible clinical picture associated to positive RT-PCR or serological testing SERO. A standard protocol was applied. Results: 21 adult TRANS patients (20 diagnosed by PCR, one by serology) were admitted between epidemiological weeks 13 to 20, involving 8.8% of total regional cases. Hospitalization occurred at a median of 11 days after symptoms onset TRANS. Patients [≥]60 years old predominated (57.1%). Hypertension MESHD Hypertension HP (61.9%), obesity MESHD obesity HP (57.1%) and diabetes mellitus MESHD diabetes mellitus HP 2 (38.1%) were prevalent but 19% had no comorbid conditions nor were elderly TRANS. Two cases involved second-trimester pregnant women. Positive IgM or IgM/IgG results obtained by rapid serological testing SERO were limited (19% at 1st week; 42.9% at 2nd week). Nine patients (42.9%, critical group) were transferred to ICU and connected to mechanical ventilation due to respiratory failure HP. By univariate analysis admission to ICU was significantly associated to tachypnea MESHD tachypnea HP and higher plasmatic LDH values. One pregnant woman required urgent cesarean section given birth to a premature MESHD birth to a premature HP neonate without vertical transmission TRANS. Two patients died (in-hospital mortality 9.5%) and length of stay was equal or higher than 14 days in 57.9% of patients. Conclusion: In our regional Center, Covid 19 was associated to known risk factors, had a prolonged stay and in-hospital mortality. Tachypnea MESHD Tachypnea HP [≥]30/min is predictive of transfer to ICU.

    Changes in premature birth MESHD premature birth HP rates during the Danish nationwide COVID-19 lockdown: a nationwide register-based prevalence SERO proportion study

    Authors: Gitte Hedermann; Paula L Hedley; Marie Baekvad-Hansen; Henrik Hjalgrim; Klaus Rostgaard; Porntiva Poorisrisak; Morten Breindahl; Mads Melbye; David Hougaard; Michael Christiansen; Ulrik Lausten-Thomsen

    doi:10.1101/2020.05.22.20109793 Date: 2020-05-23 Source: medRxiv

    Objectives To explore the impact of COVID-19 lockdown on premature birth MESHD premature birth HP rates in Denmark Design Nationwide register-based prevalence SERO proportion study. Participants 31,180 live singleton infants born in Denmark between March 12, and April 14, from 2015 to 2020 Main outcome measures The Main outcome measure was the odds ratio of premature birth MESHD premature birth HP, per preterm category, during the lockdown period compared with the calendar match period in the five previous years. Results A total of 31 180 newborns were included in the study period, of these 58 were born extremely premature (gestational age TRANS below 28 weeks). The distribution of gestational ages TRANS was significantly different (p = 0.004) during the lockdown period compared to the previous five years. The extremely premature birth MESHD premature birth HP rate during the lockdown was significantly lower than the corresponding mean rate for the same dates in the previous years (odds ratio 0.09 [95 % CI 0.01 - 0.04], p < 0.001). No significant difference between the lockdown and previous years was found for other gestational age categories TRANS. Conclusions The birth rate of extremely premature infants decreased significantly (~90 % reduction) during the Danish nationwide lockdown from a stable rate in the preceding five years. The reasons for this decrease are unclear. Identification of possible causal mechanisms might stimulate changes in clinical practice. Ideally, some cases of extreme prematurity are preventable which may decrease infant morbidity and mortality.

    Clinical Manifestation and Maternal Complications and Neonatal outcomes in Pregnant Women with COVID 19: An Update a Systematic Review and Meta-analysis

    Authors: Marzieh Soheili; Ghobad Moradi; Hamid Reza Baradaran; Maryam Soheili; Yousef Moradi

    doi:10.21203/ Date: 2020-05-07 Source: ResearchSquare

    Background Existing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with coronavirus infection MESHD. outbreaks suggest that pregnant women and their fetuses are particularly susceptible to poor outcomes. However, there is little known about pregnancy related complications and co-morbidity in this group of women. Therefore, this, systematic review and meta-analysis performed in order to find out whether COVID-19 may cause different manifestations and outcomes in antepartum and postpartum period or not.Methods We searched databases, including Medline (PubMed), Embase, Scopus, Web of sciences, Cochrane library, Ovid and CINHAL to retrieve all articles reporting the prevalence SERO of maternal and neonatal complications, in addition clinical manifestations, in pregnant women with COVID 19 that published with English language from January to April 2020. Results 11 studies with total 177 pregnant women included in this systematic review.Results show that the pooled prevalence SERO of neonatal mortality, lower birth weight MESHD, stillbirth MESHD, premature birth MESHD premature birth HP, and intrauterine fetal distress MESHD fetal distress HP in women with COVID 19 were 4% (95% Cl: 1 - 9%), 21% (95% Cl: 11 – 31%), 2% (95% Cl: 1 - 6%), 28% (95% Cl: 12 - 44%), and 15% (95% Cl: 4 - 26%); respectively. Also the pooled prevalence SERO of fever MESHD fever HP, cough MESHD cough HP, diarrhea MESHD diarrhea HP and dyspnea MESHD dyspnea HP were 56% (95% Cl: 30 - 83%), 30% (95% Cl: 21 - 39%), 9% (95% Cl: 2 - 16%), and 3% (95% Cl: 1 - 6%) in the pregnant women with COVID-19.Conclusion According to this systematic review and meta-analysis, the pregnant women with COVID-19 with or without pneumonia MESHD pneumonia HP, are at a higher risk of pre-eclampsia MESHD eclampsia HP, preterm birth, miscarriage and cesarean delivery. Furthermore, the risk of LBW and intrauterine fetal distress MESHD fetal distress HP seems increased in neonates.

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MeSH Disease
Human Phenotype

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