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    Hydroxychloroquine/ Chloroquine in Patients With COVID-19 in Wuhan, China: A Retrospective Study

    Authors: Zhe Chen; Aihua Liu; Yongjing Cheng; Xutao Wang; Xiaomao Xu; Jia Huang; Yuqing Ma; Ming Gao; Cibo Huang

    doi:10.21203/rs.3.rs-52334/v1 Date: 2020-08-01 Source: ResearchSquare

    Background: We aim to evaluate the treatment value and safety of hydroxychloroquine (HCQ)/ chloroquine (CQ) in COVID-19.Methods: We retrospectively reviewed the medical charts of patients with COVID-19 admitted to an inpatient ward in Wuhan from 2020. 02. 08 to 2020. 03. 05. Patients with HCQ/ CQ and age TRANS, gender TRANS, disease severity matched ones without HCQ/ CQ were selected at a 1:2 ratio. The clinical, laboratory and imaging findings were compared between these two groups. The multivariate linear regression analysis was performed to identify the factors that might influence patients’ virus shedding periods (VSPs).Results: A total of 14 patients with HCQ/ CQ and 21 matched were analyzed. The HCQ/CQ treatment lasted for an average of 10.36±3.12 days. The VSPs were a little longer in the HCQ/ CQ treatment group (26.57±10.35 days vs. 19.10±7.80 days, P=0.020). There were 3 patients deceased during inpatient period, two patients were with HCQ/ CQ treatment (P=0.551). In the multivariate linear regression analysis, disease durations at admission (t=3.643, P=0.001) and HCQ/CQ treatment (t=2.637, P=0.013) were independent parameters for patients’ VSPs prediction. One patient with CQ had recurrent first-degree atrioventricular block HP atrioventricular block MESHD ( AVB MESHD) and obvious QTc elongation, another one complained about dizziness MESHD and blurred vision HP blurred vision MESHD which disappeared after CQ discontinuation. One patient with HCQ had transient AVB MESHD.Conclusions: The HCQ/ CQ administration is not related to neither less mortality cases nor shorter VSPs. HCQ rather than CQ is relative safe and tolerable.

    Electrocardiographic findings of methanol toxicity MESHD: A cross-sectional study on 356 cases in Iran

    Authors: Mohammad Hossein Nikoo; Alireza Arjangzadeh; Maryam Pakfetrat; Shahrokh Sadeghi Boogar; Vahid Mohammadkarimi; Vahid Reza Ostovan; Zohre Khodamoradi; Jamshid Roozbeh; Mohammadreza Khalili; Farnaz Kamali Haghighi Shirazi; Paryia Kouhi; Seyyed Taghi Heydari

    doi:10.21203/rs.3.rs-34297/v2 Date: 2020-06-08 Source: ResearchSquare

    Background: Methanol is widely used in industry; however, methanol poisoning is not common. In this regard, a number of outbreaks have been recently reported due to inappropriate processing of alcoholic beverages. Shiraz, a city located in the southern part of Iran, faced one of such outbreaks in 2020 during COVID-19 pandemic. There is no sufficient literature on the electrocardiographic findings in methanol toxicity MESHD. This study aimed to address this gap in the literature.Method: A total of 356 cases with methanol toxicity MESHD referred to Shiraz University of Medical Science Tertiary Hospitals (Faghihi and Namazi) in March and April, 2020. The clinical findings of blindness HP blindness MESHD and impaired level of consciousness, lab data such as arterial blood SERO gas, electrolytes, and creatinine, and the most common findings from ECGs were collected. Results: The most common ECG findings were J point elevation (68.8%), presence of U wave (59.2%), QTc prolongation MESHD (53.2% in males TRANS and 28.6% in females TRANS), and fragmented QRS (33.7%). An outstanding finding in this study was the presence of myocardial infarction HP myocardial infarction MESHD in 5.3% of the cases. This finding, to the best of our knowledge, has only been reported in a few case reports. Brugada pattern (8.1%) and Osborn wave (3.7%) were the other interesting findings.In multivariate analysis, when confounding factors were adjusted, myocardial infarction HP myocardial infarction MESHD, atrioventricular conduction disturbances MESHD, sinus tachycardia HP sinus tachycardia MESHD, and the prolonged QTC>500 msecond were four independent factors correlated with methanol toxicity MESHD severity measured with arterial blood SERO PH on arterial blood SERO gas measurements, with odds ratios of 12.82, 4.46, 2.32 and 3.15 (P<0.05 for all) , respectively.Conclusion: Electrocardiographic variations during methanol intoxication are remarkable and well-correlated with poisoning severity. Myocardial infarction HP Myocardial infarction MESHD was an egregious and yet a common concerning finding in this sample, which need to be ruled out in methanol toxicity MESHD.

    Electrocardiographic findings of methanol toxicity MESHD: A cross-sectional study on 356 cases in Iran

    Authors: Mohammad Hossein Nikoo; Alireza Arjangzadeh; Maryam Pakfetrat; Shahrokh Sadeghi Boogar; Vahid Mohammadkarimi; Vahid Reza Ostovan; Zohre Khodamoradi; Jamshid Roozbeh; Mohammadreza Khalili; Farnaz Kamali Haghighi Shirazi; Paryia Kouhi; Seyyed Taghi Heydari

    doi:10.21203/rs.3.rs-34297/v3 Date: 2020-06-08 Source: ResearchSquare

    Background : Methanol is widely used in industry; however, methanol poisoning is not common. In this regard, a number of outbreaks have been recently reported due to inappropriate processing of alcoholic beverages. Shiraz, a city located in the southern part of Iran, faced one of such outbreaks in 2020 during COVID-19 pandemic. There is no sufficient literature on the electrocardiographic findings in methanol toxicity MESHD. This study aimed to address this gap in the literature. Method : A total of 356 cases with methanol toxicity MESHD referred to Shiraz University of Medical Science Tertiary Hospitals (Faghihi and Namazi) in March and April, 2020. The clinical findings of blindness HP blindness MESHD and impaired level of consciousness, lab data such as arterial blood SERO gas, electrolytes, and creatinine, and the most common findings from ECGs were collected. Results : The most common ECG findings were J point elevation (68.8%), presence of U wave (59.2%), QTc prolongation MESHD (53.2% in males TRANS and 28.6% in females TRANS), and fragmented QRS (33.7%). An outstanding finding in this study was the presence of myocardial infarction HP myocardial infarction MESHD in 5.3% of the cases. This finding, to the best of our knowledge, has only been reported in a few case reports. Brugada pattern (8.1%) and Osborn wave (3.7%) were the other interesting findings. In multivariate analysis, when confounding factors were adjusted, myocardial infarction HP myocardial infarction MESHD, atrioventricular conduction disturbances MESHD, sinus tachycardia HP sinus tachycardia MESHD, and the prolonged QTC>500 msecond were four independent factors correlated with methanol toxicity MESHD severity measured with arterial blood SERO PH on arterial blood SERO gas measurements, with odds ratios of 12.82, 4.46, 2.32 and 3.15 (P<0.05 for all) , respectively. Conclusion : Electrocardiographic variations during methanol intoxication are remarkable and well-correlated with poisoning severity. Myocardial infarction HP Myocardial infarction MESHD was an egregious and yet a common concerning finding in this sample, which need to be ruled out in methanol toxicity MESHD.

    Deteriorating Atrioventricular Block HP Atrioventricular Block MESHD in COVID-19 Suspected Patient after Receiving Initial Dose of Azythromycin and Hydroxychloroquine

    Authors: Billy Aditya Pratama; Afik Maulana Rachman; Vita Yanti Anggraeni; Erika Maharani; Ika Trisnawati; Bambang Sigit Riyanto; Anggoro Budi Hartopo

    id:10.20944/preprints202005.0190.v1 Date: 2020-05-11 Source: Preprints.org

    Coronavirus 2019 (COVID-19) is an infectious disease MESHD that is becoming a pandemic. Hydroxychloroquine in combination with azythromycin are among drugs currently in use to eradicate COVID-19. Despite concerns due to its potential cardiac toxicity MESHD, hydroxychloroquine is widely accepted in mild and moderate COVID-19 pneumonia HP pneumonia MESHD. In this case report, we report a case of a young Indonesian adult TRANS male TRANS with suspected COVID-19 pneumonia HP pneumonia MESHD who received hydroxychloroquine and azythromycin therapies and during 24 hour experienced deterioration of atrioventricular block MESHD atrioventricular block HP.

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Human Phenotype
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