Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (406)

Fever (387)

Hypertension (314)

Cough (298)

Anxiety (194)


Transmission

age categories (3444)

gender (1213)

Transmission (536)

fomite (292)

contact tracing (286)


Seroprevalence
    displaying 1441 - 1450 records in total 3444
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    Healthy Lifestyle Behaviors Are Major Predictors of Mental Wellbeing During COVID-19 Pandemic Confinement: A Study on Adult TRANS Arabs in Higher Educational Institutions

    Authors: hashem A. Kilani; Mo'ath F Bataineh,; Ali Al-Nawayseh; Khaled Atyat; Omar Obeid; Maher M. Abu-Hilal; Taiysir Mansi; Maher AlKilani; Mahfooda Al-Kitani; Ruba M. Jaber; Ahmad Sweidan; Mawaheb Himsi; Iyad Yousef; Faten Alzeer; Monther Nasrallah; Ayesha S Al Dhaheri; Abdulsalam Al-Za’abi; Osama Allala; Laila Al-Kilani; Majed El-Saleh; Asma M Alhasan; Mohamed Ghieda; Yasir Najah; Saad Alsheekhly; Ahmad Alhaifi; Raghda Shukri; Jamal Al Adwani; Mostafa Waly; Laila H. Kilani; Leen H Kilani; Ahmad S Al Shareef; Areej H. Kilani

    doi:10.21203/rs.3.rs-37899/v1 Date: 2020-06-25 Source: ResearchSquare

    Background In previous times, infectious diseases MESHD affected the quality of human life during home confinement. This study investigated the influence of home confinement during the COVID-19 pandemic outbreak on lifestyle, mental wellbeing, nutritional status, and sleeping pattern.Method: An online multicategory questionnaire was distributed to collect Demographical information and combined the following tools: Food Frequency Questionnaire (FFQ), International Physical Activity Questionnaire (IPAQ), WHO-5 wellbeing score, and Pittsburgh Sleep Quality Index (PSQI). A snowball none-discriminate sampling procedure was followed to collect data from people attending or working at higher institution had covering the period between Mar/00/2020 and Apr/24/2020. A total of 1723 completed responses (917 Males TRANS 37.4 ± 13.4 yrs. old and (806 Females TRANS 32.2 ± 11.5 yrs. old) were collected.Results Female TRANS participants had significantly lower mental health scores as compared to males TRANS (53.9% vs 46.1%). on Mental wellbeing score was better among participants with medium and high Physical Activity Levels (p < 0.00). Additionally, mental wellbeing score was significantly improved by dietary quality and sleeping score (p < 0.001). However, physical activity was by far the major determinants of mental health score.Conclusion Factors such as PA, Diet, sleeping patterns were associated with mental wellbeing during COVID-19 confinement among Arab participants.

    Awareness and Readiness of COVID-19 among Bangladeshi Residents

    Authors: Mili Saha; Goutam Saha

    id:202005.0370/v2 Date: 2020-06-25 Source: Preprints.org

    Bangladesh has adopted some special steps to control the quick spread of the COVID-19 pandemic situation. However, the local residents’ knowledge, attitudes, and practices towards the disease have a direct impact on the success of the controlling measures taken by the state. This article explores knowledge (K) about preventions, attitude (A) to the disease, and practices (P) of preventing COVID-19 situation of the young age groups TRANS residing in Bangladesh. Quantitative data were collected online using a KAP questionnaire from 932 participants. Results show the population is generally aware of the symptoms, keeping social distance by staying home and are concerned about re-spreading after the lock-down period. However, they are quite unsure about the possible medicines frequently talked about in the media and the necessity of avoiding animal protein. One of the major limitations is, these findings should not be generalized due to the low number of participants compared to the total population in Bangladesh.

    Number of Pre-Existing Comorbidities and Prognosis of COVID-19: A Retrospective Cohort Study

    Authors: Danrong Jing; Juan Su; Lin Ye; Yan Zhang; Yanhui Cui; Hong Liu; Minxue Shen; Pinhua Pan; Xiang Chen

    doi:10.21203/rs.3.rs-37929/v1 Date: 2020-06-25 Source: ResearchSquare

    Background: Though many studies have described the association of coronavirus disease MESHD 2019 (COVID-19) and different kinds of noncommunicable chronic diseases, information with the combine effects of comorbidities to COVID-19 patients have not been well characterized yet. The aim of this study was to examine the associations of numbers of comorbidities with critical type and death of COVID-19.Methods: This was a single-centered retrospective study among patients with COVID-19. All patients with COVID-19 enrolled in this study were diagnosed according to World Health Organization interim guidance. Six different kinds of noncommunicable chronic diseases were included in this study. The logistic regression model was used to estimate the fixed effect of numbers of comorbidities on critical type or death MESHD, adjusting for potential confounders.Results: In total, 475 COVID-19 patients were enrolled in our study, included 234 females TRANS and 241 males TRANS. Hypertension HP Hypertension MESHD was the most frequent type (162 [34.1%] of 475 patients). Patients with two or more comorbidities have higher risk of critical type (OR 3.072, 95% CI [1.581, 5.970], p=0.001) and death MESHD (OR 5.538, 95% CI [1.577, 19.451], p=0.008) compared to patients without comorbidities. And the results were similar after adjusting for age TRANS and gender TRANS in critical type (OR 2.021, 95% CI [1.002–4.077], p=0.049) and death MESHD (OR 3.653, 95% CI [0.989, 13.494], p=0.052).Conclusions: The number of comorbidities was an independent risk factor for critical type and death in COVID-19 patients.

    Shut and re-open: the role of schools in the spread of COVID-19 in Europe

    Authors: Helena B. Stage; Joseph Shingleton; Sanmitra Ghosh; Francesca Scarabel; Lorenzo Pellis; Thomas Finnie

    id:2006.14158v1 Date: 2020-06-25 Source: arXiv

    We investigate the effect of school closure and subsequent reopening on the transmission TRANS of COVID-19, by considering Denmark, Norway, Sweden, and German states as case studies. By comparing the growth rates in daily hospitalisations or confirmed cases TRANS under different interventions, we provide evidence that the effect of school closure is visible as a reduction in the growth rate approximately 9 days after implementation. Limited school attendance, such as older students sitting exams or the partial return of younger year groups TRANS, does not appear to significantly affect community transmission TRANS. A large-scale reopening of schools while controlling or suppressing the epidemic appears feasible in countries such as Denmark or Norway, where community transmission TRANS is generally low. However, school reopening can contribute to significant increases in the growth rate in countries like Germany, where community transmission TRANS is relatively high. Our findings underscore the need for a cautious evaluation of reopening strategies that ensure low classroom occupancy and a solid infrastructure to quickly identify and isolate new infections.

    Strategies for Controlling the Spread of COVID-19

    Authors: Eric Forgoston; Michael Thorne

    doi:10.1101/2020.06.24.20139014 Date: 2020-06-25 Source: medRxiv

    We consider a deterministic epidemiological compartmental model that includes age TRANS and social contact structure for the COVID-19 crisis and explore the consequences of different strategies for easing current lockdown measures that are in place in many countries. We apply the model to the specific circumstances in the state of New Jersey, in the United States of America. As expected, only a rigorous program of testing, tracing TRANS and isolation of cases will allow the state to ease its lockdown with a reduced number of deaths MESHD. We also find that a slightly earlier date of lockdown, while reducing the number of deaths in the short term, will only reduce the total number of deaths MESHD in the long run if the ensuing strategies in easing the lockdown are carried out with the aforementioned test, trace TRANS and isolation program. Otherwise, a slightly earlier lockdown will result in increased deaths as the expected second wave of infection sweeps through the state in the coming months.

    Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease MESHD

    Authors: Muhamed-Kheir Taha; Ala-Eddine Deghmane

    doi:10.21203/rs.3.rs-37726/v1 Date: 2020-06-24 Source: ResearchSquare

    Objective: Few data are available on the association between SARS-CoV-2 and secondary bacterial infections MESHD. Such an association was described for flu and invasive meningococcal disease MESHD ( IMD MESHD). We aimed exploring such a correlation between COVID-19and IMD MESHD.Results: We compared IMD MESHD cases received at the French National Reference Centre for meningococci and Haemophilus MESHD influenzae that are sent as part of the mandatory reporting of IMD MESHD. We compared these data during the period 01 January-15 May 2020 to those from the same period in 2019. IMD MESHD cases that were associated with respiratory presentations significantly increased in 2020, involved elderly TRANS and were due to unusual isolates. However, usual IMD MESHD cases due to highly transmissible isolates decreased during the lockdown. Enhancing IMD MESHD surveillance and anti- meningococcal MESHD vaccination in elderly TRANS should to be addressed.

    Lung expression of genes encoding SARS-CoV-2 cell entry molecules and antiviral restriction factors: interindividual differences are associated with age TRANS and germline variants

    Authors: Chiara E. Cotroneo; Nunzia Mangano; Tommaso A. Dragani; Francesca Colombo

    doi:10.1101/2020.06.24.168534 Date: 2020-06-24 Source: bioRxiv

    Germline variants in genes involved in SARS-CoV-2 cell entry (i.e. ACE2 and TMPRSS2) may influence the susceptibility to infection, as may polymorphisms in genes involved in the innate host response to viruses (e.g. APOBEC3 family). We searched for polymorphisms acting, in lung tissue, as expression quantitative trait loci (eQTLs) for 15 candidate COVID-19 susceptibility genes, selected for their roles in virus cell entry and host antiviral responses. No significant eQTLs were identified for ACE2 and TMPRSS2 genes, whose expression levels did not associate with either sex or age TRANS of the 408 patients whose non-diseased lung tissue was analyzed. Instead, we identified seven cis-eQTLs (FDR<0.05) for APOBEC3D and APOBEC3G (rs139296, rs9611092, rs139331, rs8177832, rs17537581, rs61362448, and rs738469). The genetic control of the expression of APOBEC3 genes, which encode enzymes that interfere with virus replication, may explain interindividual differences in risk or severity of viral infections MESHD. Future studies should investigate the role of host genetics in COVID-19 patients using a genome-wide approach, to identify other genes whose expression levels are associated with susceptibility to SARS-CoV-2 infection MESHD or COVID-19 severity. Author summaryIdentification of expression quantitative trait loci (eQTLs) has become commonplace in functional studies on the role of individual genetic variants in susceptibility to diseases. In COVID-19, it has been proposed that individual variants in SARS-CoV-2 cell entry and innate host response genes may influence the susceptibility to infection. We searched for polymorphisms acting, in non-diseased lung tissue of 408 patients, as eQTLs for 15 candidate COVID-19 susceptibility genes, selected for their roles in virus cell entry and host antiviral responses. Seven cis-eQTLs were detected for APOBEC3D and APOBEC3G genes, which encode enzymes that interfere with virus replication. No significant eQTLs were identified for ACE2 and TMPRSS2 genes. Therefore, the identified eQTLs may represent candidate loci modulating interindividual differences in risk or severity of SARS-CoV-2 virus infection.

    Incidence, risk factors and mortality outcome in patients with acute kidney injury HP acute kidney injury MESHD in COVID-19: a single-center observational study

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Giacomo Mori; Riccardo Magistroni; Meschiari Marianna; Franceschini Erica; Marianna Menozzi; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Paolo Raggi; Massimo Girardis; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.24.20138230 Date: 2020-06-24 Source: medRxiv

    Background Acute kidney injury HP Acute kidney injury MESHD ( AKI MESHD) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI MESHD in patients with documented COVID-19. Methods We reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. Results AKI MESHD was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI MESHD were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI MESHD patients had a mean age TRANS of 74.7 {+/-} 9.9 years and higher serum SERO levels of the main marker of inflammation MESHD and organ involvement (lung, liver, hearth and liver) than non- AKI MESHD patients. AKI MESHD events were more frequent in subjects with severe lung comprise. Two peaks of AKI MESHD events coincided with in-hospital admission and death of the patients. Kidney injury MESHD was associate with a higher rate of urinary abnormalities MESHD including proteinuria HP proteinuria MESHD (0.448{+/-} 0.85 vs 0.18 {+/-} 0.29; P=<0.0001) and hematuria HP hematuria MESHD (P=0.032) compared to non- AKI MESHD patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI MESHD. Risk factors for kidney injury MESHD were age TRANS, male TRANS sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI MESHD was independently associated with in-hospital death (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non- AKI MESHD patients. Groups of patients with AKI MESHD stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine HP serum SERO creatinine, likely due to muscle depletion occurred with prolonged bed rest. Conclusions AKI MESHD was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI MESHD and prevention of kidney injury MESHD by avoiding dehydration HP dehydration MESHD and nephrotoxic MESHD agents is imperative in this vulnerable cohort of patients.

    Does Biological Therapy Protect against Severe COVID-19?

    Authors: Ramon Mazzucchelli; Raquel Almodovar-Gonzalez; Natalia Crespi-Villarias; Elena Garcia-Zamora; Elia Perez-Fernandez; Javier Quiros-Donate; Monserrat Perez-Encinas; Patricia Sanmartin-Fenollera; Maria Velasco-Arribas; Pilar Lopez-Serrano; Jose lazaro Perez-Calle; Conrado Fernandez-Rodriguez; Jose Luis Lopez-Estebaranz; Pedro Zarco-Montejo

    doi:10.1101/2020.06.21.20136788 Date: 2020-06-24 Source: medRxiv

    Objective. To estimate COVID-19 infection MESHD incidence rate with severe affectation MESHD (requiring hospitalization) in patients with biological treatment due to rheumatoid arthritis HP rheumatoid arthritis MESHD ( RA MESHD), psoriatic arthritis MESHD arthritis HP ( PsA MESHD), spondyloarthritis MESHD ( SpA MESHD), psoriasis MESHD ( Ps MESHD), and inflammatory bowel disease MESHD ( IBD MESHD) and compare it with incidence rate in the general population. Methods: Retrospective observational study based on information provided by two administrative databases. One of these two databases contains information on all patients seen in our hospital and diagnosed with COVID-19 infection between March 4th 2020 and April 26th 2020. The other database contains data from patients seen at Rheumatology, Dermatology and Digestive Departments in our hospital who are currently receiving biological therapy. We calculated the crude and age TRANS and sex adjusted incidence in both groups. To compare both groups we calculated the Incidence Rate Ratio. Results: There was a total of 2,182 patients with COVID-19 requiring hospitalization. Four patients out of a total of 797 patients receiving biological therapy had contracted COVID-19 and required hospital care. Crude incidence rate of COVID-19 requiring hospital care among the general population was 1.41%, and it was 0.50% among the group receiving biological therapy. Rates adjusted by age TRANS and sex in the biological group was 0.45% (CI95% 0.11-4.13). The IRR of the group receiving biological therapy compared to the general population was 0.39 (CI95% 0.14-1, p=0.049). Conclusion: Findings suggest that prior use of biological therapy does not associate with severe manifestations of COVID-19, and it is likely to have a protective effect against them when compared to the general population.

    Seroprevalence SERO of SARS-CoV-2 IgG significantly varies with age TRANS: results from a mass population screening (SARS-2-SCREEN-CdA).

    Authors: Gabriele Pagani; Federico Conti; Andrea Giacomelli; Dario Bernacchia; Rossana Rondanin; Andrea Prina; Vittore Scolari; Cecilia Eugenia Gandolfi; Silvana Castaldi; Giuseppe Marano; Cosimo Ottomano; Patrizia Boracchi; Elia Mario Biganzoli; Massimo Galli

    doi:10.1101/2020.06.24.20138875 Date: 2020-06-24 Source: medRxiv

    Castiglione D'Adda is one of the towns earlier and more severely affected by the SARS-CoV-2 epidemic in Lombardy. In a mass screening involving 4174 out of about 4550 total inhabits, significant age TRANS-related differences in anti SARS-CoV-2 IgG seroprevalence SERO were found, with the lowest prevalence SERO in the youngest inhabitants.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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