Background: The COVID-19 pandemic has caused substantial disruptions to health services in the low and middle-income countries with a high burden of other diseases MESHD, such as malaria MESHD in sub-Saharan Africa. As the COVID-19 pandemic spread to Africa, there is an urgent need to assess the impact of COVID-19 pandemic on malaria MESHD transmission TRANS potential in malaria MESHD-endemic countries in Africa.Methods: We present a data-driven method to quantify the extent to which the COVID-19 pandemic, as well as various non-pharmaceutical interventions (NPIs), could lead to the change of malaria MESHD transmission TRANS potential in 2020. First, we adopt a particle Markov Chain Monte Carlo method to estimate epidemiological parameters in each country by fitting the time series of the cumulative number of COVID-19 cases. Then, we simulate the epidemic dynamics of COVID-19 under two groups of NPIs: (i) contact restriction and social distancing, and (ii) early identification and isolation of cases. Based on the simulated epidemic curves, we quantify the impact of COVID-19 epidemic and NPIs on the distribution of insecticide-treated nets (ITNs). Finally, by treating the total number of ITNs available in each country in 2020, we evaluate the negative effects of COVID-19 pandemic on malaria MESHD transmission TRANS potential based on the notion of vectorial capacity.Results: We conduct case studies in four malaria MESHD-endemic countries, Ethiopia, Nigeria, Tanzania, and Zambia, in Africa. The epidemiological parameters (i.e., the basic reproduction number TRANS R0 TRANS and the duration of infection MESHD DI ) of COVID-19 in each country are estimated as follows: Ethiopia ( R0 TRANS = 1:57, DI = 5:32), Nigeria ( R0 TRANS = 2:18, DI = 6:58), Tanzania ( R0 TRANS = 2:47, DI = 6:01), and Zambia ( R0 TRANS = 2:12, DI = 6:96). Based on the estimated epidemiological parameters, the epidemic curves simulated under various NPIs indicated that the earlier the interventions are implemented, the better the epidemic is controlled. Moreover, the effect of combined NPIs is better than contact restriction and social distancing only. By treating the total number of ITNs available in each country in 2020 as a baseline, our results show that even with stringent NPIs, malaria MESHD transmission TRANS potential will remain higher than expected in the second half of 2020.Conclusions: By quantifying the impact of various NPI response to the COVID-19 pandemic on malaria MESHD transmission TRANS potential, this study provides a way to jointly address the syndemic between COVID-19 and malaria MESHD in malaria MESHD-endemic countries in Africa. The results suggest that the early intervention of COVID-19 can effectively reduce the scale of the epidemic and mitigate its impact on malaria MESHD transmission TRANS potential.